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A p53-dependent response limits the viability of mammalian haploid cells.
Olbrich T, Mayor-Ruiz C, Vega-Sendino M, Gomez C, Ortega S, Ruiz S, Fernandez-Capetillo O. Olbrich T, et al. Among authors: vega sendino m. Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):9367-9372. doi: 10.1073/pnas.1705133114. Epub 2017 Aug 14. Proc Natl Acad Sci U S A. 2017. PMID: 28808015 Free PMC article.
ERF deletion rescues RAS deficiency in mouse embryonic stem cells.
Mayor-Ruiz C, Olbrich T, Drosten M, Lecona E, Vega-Sendino M, Ortega S, Dominguez O, Barbacid M, Ruiz S, Fernandez-Capetillo O. Mayor-Ruiz C, et al. Among authors: vega sendino m. Genes Dev. 2018 Apr 1;32(7-8):568-576. doi: 10.1101/gad.310086.117. Epub 2018 Apr 12. Genes Dev. 2018. PMID: 29650524 Free PMC article.
CTCF is a barrier for 2C-like reprogramming.
Olbrich T, Vega-Sendino M, Tillo D, Wu W, Zolnerowich N, Pavani R, Tran AD, Domingo CN, Franco M, Markiewicz-Potoczny M, Pegoraro G, FitzGerald PC, Kruhlak MJ, Lazzerini-Denchi E, Nora EP, Nussenzweig A, Ruiz S. Olbrich T, et al. Among authors: vega sendino m. Nat Commun. 2021 Aug 11;12(1):4856. doi: 10.1038/s41467-021-25072-x. Nat Commun. 2021. PMID: 34381034 Free PMC article.
Transcription factor Tox2 is required for metabolic adaptation and tissue residency of ILC3 in the gut.
Das A, Martinez-Ruiz GU, Bouladoux N, Stacy A, Moraly J, Vega-Sendino M, Zhao Y, Lavaert M, Ding Y, Morales-Sanchez A, Harly C, Seedhom MO, Chari R, Awasthi P, Ikeuchi T, Wang Y, Zhu J, Moutsopoulos NM, Chen W, Yewdell JW, Shapiro VS, Ruiz S, Taylor N, Belkaid Y, Bhandoola A. Das A, et al. Among authors: vega sendino m. Immunity. 2024 Apr 18:S1074-7613(24)00206-1. doi: 10.1016/j.immuni.2024.04.001. Online ahead of print. Immunity. 2024. PMID: 38677292
The homeobox transcription factor DUXBL controls exit from totipotency.
Vega-Sendino M, Lüttmann FF, Olbrich T, Chen Y, Kuenne C, Stein P, Tillo D, Carey GI, Zhong J, Savy V, Radonova L, Lu T, Saykali B, Kim KP, Domingo CN, Schüler L, Günther S, Bentsen M, Bosnakovski D, Schöler H, Kyba M, Maity TK, Jenkins LM, Looso M, Williams CJ, Kim J, Ruiz S. Vega-Sendino M, et al. Nat Genet. 2024 Apr;56(4):697-709. doi: 10.1038/s41588-024-01692-z. Epub 2024 Mar 20. Nat Genet. 2024. PMID: 38509386