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Regulatory T-cell Depletion Alters the Tumor Microenvironment and Accelerates Pancreatic Carcinogenesis.
Zhang Y, Lazarus J, Steele NG, Yan W, Lee HJ, Nwosu ZC, Halbrook CJ, Menjivar RE, Kemp SB, Sirihorachai VR, Velez-Delgado A, Donahue K, Carpenter ES, Brown KL, Irizarry-Negron V, Nevison AC, Vinta A, Anderson MA, Crawford HC, Lyssiotis CA, Frankel TL, Bednar F, Pasca di Magliano M. Zhang Y, et al. Among authors: velez delgado a. Cancer Discov. 2020 Mar;10(3):422-439. doi: 10.1158/2159-8290.CD-19-0958. Epub 2020 Jan 7. Cancer Discov. 2020. PMID: 31911451 Free PMC article.
Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-κB-Mediated Production of CXCL1.
Kemp SB, Carpenter ES, Steele NG, Donahue KL, Nwosu ZC, Pacheco A, Velez-Delgado A, Menjivar RE, Lima F, The S, Espinoza CE, Brown K, Long D, Lyssiotis CA, Rao A, Zhang Y, Pasca di Magliano M, Crawford HC. Kemp SB, et al. Among authors: velez delgado a. Cancer Res. 2021 Aug 15;81(16):4305-4318. doi: 10.1158/0008-5472.CAN-20-3929. Epub 2021 May 28. Cancer Res. 2021. PMID: 34049975 Free PMC article.
Extrinsic KRAS Signaling Shapes the Pancreatic Microenvironment Through Fibroblast Reprogramming.
Velez-Delgado A, Donahue KL, Brown KL, Du W, Irizarry-Negron V, Menjivar RE, Lasse Opsahl EL, Steele NG, The S, Lazarus J, Sirihorachai VR, Yan W, Kemp SB, Kerk SA, Bollampally M, Yang S, Scales MK, Avritt FR, Lima F, Lyssiotis CA, Rao A, Crawford HC, Bednar F, Frankel TL, Allen BL, Zhang Y, Pasca di Magliano M. Velez-Delgado A, et al. Cell Mol Gastroenterol Hepatol. 2022;13(6):1673-1699. doi: 10.1016/j.jcmgh.2022.02.016. Epub 2022 Mar 1. Cell Mol Gastroenterol Hepatol. 2022. PMID: 35245687 Free PMC article.
Combinatorial Gli activity directs immune infiltration and tumor growth in pancreatic cancer.
Scales MK, Velez-Delgado A, Steele NG, Schrader HE, Stabnick AM, Yan W, Mercado Soto NM, Nwosu ZC, Johnson C, Zhang Y, Salas-Escabillas DJ, Menjivar RE, Maurer HC, Crawford HC, Bednar F, Olive KP, Pasca di Magliano M, Allen BL. Scales MK, et al. Among authors: velez delgado a. PLoS Genet. 2022 Jul 22;18(7):e1010315. doi: 10.1371/journal.pgen.1010315. eCollection 2022 Jul. PLoS Genet. 2022. PMID: 35867772 Free PMC article.
Arginase 1 is a key driver of immune suppression in pancreatic cancer.
Menjivar RE, Nwosu ZC, Du W, Donahue KL, Hong HS, Espinoza C, Brown K, Velez-Delgado A, Yan W, Lima F, Bischoff A, Kadiyala P, Salas-Escabillas D, Crawford HC, Bednar F, Carpenter E, Zhang Y, Halbrook CJ, Lyssiotis CA, Pasca di Magliano M. Menjivar RE, et al. Among authors: velez delgado a. Elife. 2023 Feb 2;12:e80721. doi: 10.7554/eLife.80721. Elife. 2023. PMID: 36727849 Free PMC article.