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Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.
Melero R, Rajagopalan S, Lázaro M, Joerger AC, Brandt T, Veprintsev DB, Lasso G, Gil D, Scheres SH, Carazo JM, Fersht AR, Valle M. Melero R, et al. Among authors: veprintsev db. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):557-62. doi: 10.1073/pnas.1015520107. Epub 2010 Dec 22. Proc Natl Acad Sci U S A. 2011. PMID: 21178074 Free PMC article.
The central region of HDM2 provides a second binding site for p53.
Yu GW, Rudiger S, Veprintsev D, Freund S, Fernandez-Fernandez MR, Fersht AR. Yu GW, et al. Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1227-32. doi: 10.1073/pnas.0510343103. Epub 2006 Jan 23. Proc Natl Acad Sci U S A. 2006. PMID: 16432196 Free PMC article.
Cooperative binding of tetrameric p53 to DNA.
Weinberg RL, Veprintsev DB, Fersht AR. Weinberg RL, et al. Among authors: veprintsev db. J Mol Biol. 2004 Aug 27;341(5):1145-59. doi: 10.1016/j.jmb.2004.06.071. J Mol Biol. 2004. PMID: 15321712
Core domain interactions in full-length p53 in solution.
Veprintsev DB, Freund SM, Andreeva A, Rutledge SE, Tidow H, Cañadillas JM, Blair CM, Fersht AR. Veprintsev DB, et al. Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2115-9. doi: 10.1073/pnas.0511130103. Epub 2006 Feb 6. Proc Natl Acad Sci U S A. 2006. PMID: 16461914 Free PMC article.
Targeted rescue of a destabilized mutant of p53 by an in silico screened drug.
Boeckler FM, Joerger AC, Jaggi G, Rutherford TJ, Veprintsev DB, Fersht AR. Boeckler FM, et al. Among authors: veprintsev db. Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10360-5. doi: 10.1073/pnas.0805326105. Epub 2008 Jul 23. Proc Natl Acad Sci U S A. 2008. PMID: 18650397 Free PMC article.
99 results