Verzijl D - Search Results

1

CXCR3 antagonists: quaternary ammonium salts equipped with biphenyl- and polycycloaliphatic-anchors.

Wijtmans M, Verzijl D, Bergmans S, Lai M, Bosch L, Smit MJ, de Esch IJ, Leurs R. Wijtmans M, et al. Among authors: verzijl d. Bioorg Med Chem. 2011 Jun 1;19(11):3384-93. doi: 10.1016/j.bmc.2011.04.035. Epub 2011 Apr 24. Bioorg Med Chem. 2011. PMID: 21570852

2

Synthesis and structure-activity relationship of 3-phenyl-3H-quinazolin-4-one derivatives as CXCR3 chemokine receptor antagonists.

Storelli S, Verdijk P, Verzijl D, Timmerman H, van de Stolpe AC, Tensen CP, Smit MJ, De Esch IJ, Leurs R. Storelli S, et al. Among authors: verzijl d. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2910-3. doi: 10.1016/j.bmcl.2005.03.070. Bioorg Med Chem Lett. 2005. PMID: 15911279

3

Synthesis and structure-activity relationships of 3H-quinazolin-4-ones and 3H-pyrido[2,3-d]pyrimidin-4-ones as CXCR3 receptor antagonists.

Storelli S, Verzijl D, Al-Badie J, Elders N, Bosch L, Timmerman H, Smit MJ, De Esch IJ, Leurs R. Storelli S, et al. Among authors: verzijl d. Arch Pharm (Weinheim). 2007 Jun;340(6):281-91. doi: 10.1002/ardp.200700037. Arch Pharm (Weinheim). 2007. PMID: 17562560

4

Noncompetitive antagonism and inverse agonism as mechanism of action of nonpeptidergic antagonists at primate and rodent CXCR3 chemokine receptors.

Verzijl D, Storelli S, Scholten DJ, Bosch L, Reinhart TA, Streblow DN, Tensen CP, Fitzsimons CP, Zaman GJ, Pease JE, de Esch IJ, Smit MJ, Leurs R. Verzijl D, et al. J Pharmacol Exp Ther. 2008 May;325(2):544-55. doi: 10.1124/jpet.107.134783. Epub 2008 Feb 12. J Pharmacol Exp Ther. 2008. PMID: 18270317 Free PMC article.

5

Towards small-molecule CXCR3 ligands with clinical potential.

Wijtmans M, Verzijl D, Leurs R, de Esch IJ, Smit MJ. Wijtmans M, et al. Among authors: verzijl d. ChemMedChem. 2008 Jun;3(6):861-72. doi: 10.1002/cmdc.200700365. ChemMedChem. 2008. PMID: 18442035 Review.

6

Exploring a pocket for polycycloaliphatic groups in the CXCR3 receptor with the aid of a modular synthetic strategy.

Wijtmans M, Verzijl D, van Dam CM, Bosch L, Smit MJ, Leurs R, de Esch IJ. Wijtmans M, et al. Among authors: verzijl d. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2252-7. doi: 10.1016/j.bmcl.2009.02.093. Epub 2009 Feb 27. Bioorg Med Chem Lett. 2009. PMID: 19299127

7

Pharmacological characterization of a small-molecule agonist for the chemokine receptor CXCR3.

Scholten DJ, Canals M, Wijtmans M, de Munnik S, Nguyen P, Verzijl D, de Esch IJ, Vischer HF, Smit MJ, Leurs R. Scholten DJ, et al. Among authors: verzijl d. Br J Pharmacol. 2012 Jun;166(3):898-911. doi: 10.1111/j.1476-5381.2011.01648.x. Br J Pharmacol. 2012. PMID: 21883151 Free PMC article.

8

Constitutive signaling of the human cytomegalovirus-encoded receptor UL33 differs from that of its rat cytomegalovirus homolog R33 by promiscuous activation of G proteins of the Gq, Gi, and Gs classes.

Casarosa P, Gruijthuijsen YK, Michel D, Beisser PS, Holl J, Fitzsimons CP, Verzijl D, Bruggeman CA, Mertens T, Leurs R, Vink C, Smit MJ. Casarosa P, et al. Among authors: verzijl d. J Biol Chem. 2003 Dec 12;278(50):50010-23. doi: 10.1074/jbc.M306530200. Epub 2003 Sep 30. J Biol Chem. 2003. PMID: 14522997 Free article.

9

Helix 8 of the viral chemokine receptor ORF74 directs chemokine binding.

Verzijl D, Pardo L, van Dijk M, Gruijthuijsen YK, Jongejan A, Timmerman H, Nicholas J, Schwarz M, Murphy PM, Leurs R, Smit MJ. Verzijl D, et al. J Biol Chem. 2006 Nov 17;281(46):35327-35. doi: 10.1074/jbc.M606877200. Epub 2006 Sep 22. J Biol Chem. 2006. PMID: 16997914 Free article.

10

Neutralizing nanobodies targeting diverse chemokines effectively inhibit chemokine function.

Blanchetot C, Verzijl D, Mujić-Delić A, Bosch L, Rem L, Leurs R, Verrips CT, Saunders M, de Haard H, Smit MJ. Blanchetot C, et al. Among authors: verzijl d. J Biol Chem. 2013 Aug 30;288(35):25173-25182. doi: 10.1074/jbc.M113.467969. Epub 2013 Jul 8. J Biol Chem. 2013. PMID: 23836909 Free PMC article.

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