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Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division.
Replogle JM, Zhou W, Amaro AE, McFarland JM, Villalobos-Ortiz M, Ryan J, Letai A, Yilmaz O, Sheltzer J, Lippard SJ, Ben-David U, Amon A. Replogle JM, et al. Among authors: villalobos ortiz m. Proc Natl Acad Sci U S A. 2020 Dec 1;117(48):30566-30576. doi: 10.1073/pnas.2009506117. Epub 2020 Nov 17. Proc Natl Acad Sci U S A. 2020. PMID: 33203674 Free PMC article.
BH3 profiling as pharmacodynamic biomarker for the activity of BH3 mimetics.
Pan RA, Wang Y, Qiu S, Villalobos-Ortiz M, Ryan J, Morris E, Halilovic E, Letai A. Pan RA, et al. Among authors: villalobos ortiz m. Haematologica. 2024 Apr 1;109(4):1253-1258. doi: 10.3324/haematol.2023.283060. Haematologica. 2024. PMID: 37881837 Free PMC article. No abstract available.
Prediction of venetoclax activity in precursor B-ALL by functional assessment of apoptosis signaling.
Seyfried F, Demir S, Hörl RL, Stirnweiß FU, Ryan J, Scheffold A, Villalobos-Ortiz M, Boldrin E, Zinngrebe J, Enzenmüller S, Jenni S, Tsai YC, Bornhauser B, Fürstberger A, Kraus JM, Kestler HA, Bourquin JP, Stilgenbauer S, Letai A, Debatin KM, Meyer LH. Seyfried F, et al. Among authors: villalobos ortiz m. Cell Death Dis. 2019 Jul 29;10(8):571. doi: 10.1038/s41419-019-1801-0. Cell Death Dis. 2019. PMID: 31358732 Free PMC article.