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Aging of human hematopoietic stem cells is linked to changes in Cdc42 activity.
Amoah A, Keller A, Emini R, Hoenicka M, Liebold A, Vollmer A, Eiwen K, Soller K, Sakk V, Zheng Y, Florian MC, Geiger H. Amoah A, et al. Among authors: vollmer a. Haematologica. 2022 Feb 1;107(2):393-402. doi: 10.3324/haematol.2020.269670. Haematologica. 2022. PMID: 33440922 Free PMC article.
Aging alters the epigenetic asymmetry of HSC division.
Florian MC, Klose M, Sacma M, Jablanovic J, Knudson L, Nattamai KJ, Marka G, Vollmer A, Soller K, Sakk V, Cabezas-Wallscheid N, Zheng Y, Mulaw MA, Glauche I, Geiger H. Florian MC, et al. Among authors: vollmer a. PLoS Biol. 2018 Sep 20;16(9):e2003389. doi: 10.1371/journal.pbio.2003389. eCollection 2018 Sep. PLoS Biol. 2018. PMID: 30235201 Free PMC article.
Haematopoietic stem cells in perisinusoidal niches are protected from ageing.
Saçma M, Pospiech J, Bogeska R, de Back W, Mallm JP, Sakk V, Soller K, Marka G, Vollmer A, Karns R, Cabezas-Wallscheid N, Trumpp A, Méndez-Ferrer S, Milsom MD, Mulaw MA, Geiger H, Florian MC. Saçma M, et al. Among authors: vollmer a. Nat Cell Biol. 2019 Nov;21(11):1309-1320. doi: 10.1038/s41556-019-0418-y. Epub 2019 Nov 4. Nat Cell Biol. 2019. PMID: 31685996
Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging.
Bogeska R, Mikecin AM, Kaschutnig P, Fawaz M, Büchler-Schäff M, Le D, Ganuza M, Vollmer A, Paffenholz SV, Asada N, Rodriguez-Correa E, Frauhammer F, Buettner F, Ball M, Knoch J, Stäble S, Walter D, Petri A, Carreño-Gonzalez MJ, Wagner V, Brors B, Haas S, Lipka DB, Essers MAG, Weru V, Holland-Letz T, Mallm JP, Rippe K, Krämer S, Schlesner M, McKinney Freeman S, Florian MC, King KY, Frenette PS, Rieger MA, Milsom MD. Bogeska R, et al. Among authors: vollmer a. Cell Stem Cell. 2022 Aug 4;29(8):1273-1284.e8. doi: 10.1016/j.stem.2022.06.012. Epub 2022 Jul 19. Cell Stem Cell. 2022. PMID: 35858618 Free PMC article.
Transplanting rejuvenated blood stem cells extends lifespan of aged immunocompromised mice.
Montserrat-Vazquez S, Ali NJ, Matteini F, Lozano J, Zhaowei T, Mejia-Ramirez E, Marka G, Vollmer A, Soller K, Sacma M, Sakk V, Mularoni L, Mallm JP, Plass M, Zheng Y, Geiger H, Florian MC. Montserrat-Vazquez S, et al. Among authors: vollmer a. NPJ Regen Med. 2022 Dec 29;7(1):78. doi: 10.1038/s41536-022-00275-y. NPJ Regen Med. 2022. PMID: 36581635 Free PMC article.
165 results