Wade M - Search Results

1

Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation.

Wang YV, Wade M, Wong E, Li YC, Rodewald LW, Wahl GM. Wang YV, et al. Among authors: wade m. Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12365-70. doi: 10.1073/pnas.0701497104. Epub 2007 Jul 17. Proc Natl Acad Sci U S A. 2007. PMID: 17640893 Free PMC article.

2

Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells.

Wade M, Li YC, Matani AS, Braun SM, Milanesi F, Rodewald LW, Wahl GM. Wade M, et al. Oncogene. 2012 Nov 8;31(45):4789-97. doi: 10.1038/onc.2011.625. Epub 2012 Jan 23. Oncogene. 2012. PMID: 22266850 Free PMC article.

3

Hdmx modulates the outcome of p53 activation in human tumor cells.

Wade M, Wong ET, Tang M, Stommel JM, Wahl GM. Wade M, et al. J Biol Chem. 2006 Nov 3;281(44):33036-44. doi: 10.1074/jbc.M605405200. Epub 2006 Aug 13. J Biol Chem. 2006. PMID: 16905769 Free article.

4

BH3 activation blocks Hdmx suppression of apoptosis and cooperates with Nutlin to induce cell death.

Wade M, Rodewald LW, Espinosa JM, Wahl GM. Wade M, et al. Cell Cycle. 2008 Jul 1;7(13):1973-82. doi: 10.4161/cc.7.13.6072. Cell Cycle. 2008. PMID: 18604177 Free PMC article.

5

Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry?

Wade M, Wahl GM. Wade M, et al. Mol Cancer Res. 2009 Jan;7(1):1-11. doi: 10.1158/1541-7786.MCR-08-0423. Mol Cancer Res. 2009. PMID: 19147532 Free PMC article. Review.

6

Increased radioresistance and accelerated B cell lymphomas in mice with Mdmx mutations that prevent modifications by DNA-damage-activated kinases.

Wang YV, Leblanc M, Wade M, Jochemsen AG, Wahl GM. Wang YV, et al. Among authors: wade m. Cancer Cell. 2009 Jul 7;16(1):33-43. doi: 10.1016/j.ccr.2009.05.008. Cancer Cell. 2009. PMID: 19573810 Free PMC article.

7

The p53 orchestra: Mdm2 and Mdmx set the tone.

Wade M, Wang YV, Wahl GM. Wade M, et al. Trends Cell Biol. 2010 May;20(5):299-309. doi: 10.1016/j.tcb.2010.01.009. Epub 2010 Feb 19. Trends Cell Biol. 2010. PMID: 20172729 Free PMC article. Review.

8

c-Myc, genome instability, and tumorigenesis: the devil is in the details.

Wade M, Wahl GM. Wade M, et al. Curr Top Microbiol Immunol. 2006;302:169-203. doi: 10.1007/3-540-32952-8_7. Curr Top Microbiol Immunol. 2006. PMID: 16620029 Review.

9

c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability.

Vafa O, Wade M, Kern S, Beeche M, Pandita TK, Hampton GM, Wahl GM. Vafa O, et al. Among authors: wade m. Mol Cell. 2002 May;9(5):1031-44. doi: 10.1016/s1097-2765(02)00520-8. Mol Cell. 2002. PMID: 12049739 Free article.

10

A stapled p53 helix overcomes HDMX-mediated suppression of p53.

Bernal F, Wade M, Godes M, Davis TN, Whitehead DG, Kung AL, Wahl GM, Walensky LD. Bernal F, et al. Among authors: wade m. Cancer Cell. 2010 Nov 16;18(5):411-22. doi: 10.1016/j.ccr.2010.10.024. Cancer Cell. 2010. PMID: 21075307 Free PMC article.

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