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Page 1
Tralesinidase Alfa Enzyme Replacement Therapy Prevents Disease Manifestations in a Canine Model of Mucopolysaccharidosis Type IIIB.
J Pharmacol Exp Ther. 2022 Sep;382(3):277-286. doi: 10.1124/jpet.122.001119. Epub 2022 Jun 18.
J Pharmacol Exp Ther. 2022.
PMID: 35717448
Free PMC article.
Central nervous system pathology in preclinical MPS IIIB dogs reveals progressive changes in clinically relevant brain regions.
Egeland MT, Tarczyluk-Wells MM, Asmar MM, Adintori EG, Lawrence R, Snella EM, Jens JK, Crawford BE, Wait JCM, McCullagh E, Pinkstaff J, Cooper JD, Ellinwood NM.
Egeland MT, et al. Among authors: wait jcm.
Sci Rep. 2020 Nov 23;10(1):20365. doi: 10.1038/s41598-020-77032-y.
Sci Rep. 2020.
PMID: 33230178
Free PMC article.
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Translational studies of intravenous and intracerebroventricular routes of administration for CNS cellular biodistribution for BMN 250, an enzyme replacement therapy for the treatment of Sanfilippo type B.
Grover A, Crippen-Harmon D, Nave L, Vincelette J, Wait JCM, Melton AC, Lawrence R, Brown JR, Webster KA, Yip BK, Baridon B, Vitelli C, Rigney S, Christianson TM, Tiger PMN, Lo MJ, Holtzinger J, Shaywitz AJ, Crawford BE, Fitzpatrick PA, LeBowitz JH, Bullens S, Aoyagi-Scharber M, Bunting S, O'Neill CA, Pinkstaff J, Bagri A.
Grover A, et al. Among authors: wait jcm.
Drug Deliv Transl Res. 2020 Apr;10(2):425-439. doi: 10.1007/s13346-019-00683-6.
Drug Deliv Transl Res. 2020.
PMID: 31942701
Free PMC article.
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Metabolism of [14C]gemopatrilat after oral administration to rats, dogs, and humans.
Wait JC, Vaccharajani N, Mitroka J, Jemal M, Khan S, Bonacorsi SJ, Rinehart JK, Iyer RA.
Wait JC, et al.
Drug Metab Dispos. 2006 Jun;34(6):961-70. doi: 10.1124/dmd.105.007500. Epub 2006 Mar 15.
Drug Metab Dispos. 2006.
PMID: 16540589
Clinical Trial.
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Metabolic activation of mefenamic acid leading to mefenamyl-S-acyl-glutathione adduct formation in vitro and in vivo in rat.
Grillo MP, Tadano Lohr M, Wait JC.
Grillo MP, et al.
Drug Metab Dispos. 2012 Aug;40(8):1515-26. doi: 10.1124/dmd.112.046102. Epub 2012 May 10.
Drug Metab Dispos. 2012.
PMID: 22577085
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Stereoselective flunoxaprofen-S-acyl-glutathione thioester formation mediated by acyl-CoA formation in rat hepatocytes.
Grillo MP, Wait JC, Tadano Lohr M, Khera S, Benet LZ.
Grillo MP, et al.
Drug Metab Dispos. 2010 Jan;38(1):133-42. doi: 10.1124/dmd.109.029371.
Drug Metab Dispos. 2010.
PMID: 19786506
Free PMC article.
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