Walsh CT - Search Results

1

Dihydrophenylalanine: a prephenate-derived Photorhabdus luminescens antibiotic and intermediate in dihydrostilbene biosynthesis.

Crawford JM, Mahlstedt SA, Malcolmson SJ, Clardy J, Walsh CT. Crawford JM, et al. Among authors: walsh ct. Chem Biol. 2011 Sep 23;18(9):1102-12. doi: 10.1016/j.chembiol.2011.07.009. Chem Biol. 2011. PMID: 21944749 Free PMC article.

2

Investigation of anticapsin biosynthesis reveals a four-enzyme pathway to tetrahydrotyrosine in Bacillus subtilis.

Mahlstedt SA, Walsh CT. Mahlstedt SA, et al. Among authors: walsh ct. Biochemistry. 2010 Feb 9;49(5):912-23. doi: 10.1021/bi9021186. Biochemistry. 2010. PMID: 20052993 Free PMC article.

3

Prephenate decarboxylases: a new prephenate-utilizing enzyme family that performs nonaromatizing decarboxylation en route to diverse secondary metabolites.

Mahlstedt S, Fielding EN, Moore BS, Walsh CT. Mahlstedt S, et al. Among authors: walsh ct. Biochemistry. 2010 Oct 26;49(42):9021-3. doi: 10.1021/bi101457h. Biochemistry. 2010. PMID: 20863139 Free PMC article.

4

The evolution of gene collectives: How natural selection drives chemical innovation.

Fischbach MA, Walsh CT, Clardy J. Fischbach MA, et al. Among authors: walsh ct. Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4601-8. doi: 10.1073/pnas.0709132105. Epub 2008 Jan 23. Proc Natl Acad Sci U S A. 2008. PMID: 18216259 Free PMC article.

5

The ATP-dependent amide ligases DdaG and DdaF assemble the fumaramoyl-dipeptide scaffold of the dapdiamide antibiotics.

Hollenhorst MA, Clardy J, Walsh CT. Hollenhorst MA, et al. Among authors: walsh ct. Biochemistry. 2009 Nov 3;48(43):10467-72. doi: 10.1021/bi9013165. Biochemistry. 2009. PMID: 19807062 Free PMC article.

6

Nine enzymes are required for assembly of the pacidamycin group of peptidyl nucleoside antibiotics.

Zhang W, Ntai I, Bolla ML, Malcolmson SJ, Kahne D, Kelleher NL, Walsh CT. Zhang W, et al. Among authors: walsh ct. J Am Chem Soc. 2011 Apr 13;133(14):5240-3. doi: 10.1021/ja2011109. Epub 2011 Mar 18. J Am Chem Soc. 2011. PMID: 21417270 Free PMC article.

7

NRPS substrate promiscuity diversifies the xenematides.

Crawford JM, Portmann C, Kontnik R, Walsh CT, Clardy J. Crawford JM, et al. Among authors: walsh ct. Org Lett. 2011 Oct 7;13(19):5144-7. doi: 10.1021/ol2020237. Epub 2011 Sep 2. Org Lett. 2011. PMID: 21888371 Free PMC article.

8

Three ring posttranslational circuses: insertion of oxazoles, thiazoles, and pyridines into protein-derived frameworks.

Walsh CT, Malcolmson SJ, Young TS. Walsh CT, et al. ACS Chem Biol. 2012 Mar 16;7(3):429-42. doi: 10.1021/cb200518n. Epub 2012 Jan 17. ACS Chem Biol. 2012. PMID: 22206579 Free PMC article.

9

Lessons from natural molecules.

Clardy J, Walsh C. Clardy J, et al. Nature. 2004 Dec 16;432(7019):829-37. doi: 10.1038/nature03194. Nature. 2004. PMID: 15602548 Review.

10

New antibiotics from bacterial natural products.

Clardy J, Fischbach MA, Walsh CT. Clardy J, et al. Among authors: walsh ct. Nat Biotechnol. 2006 Dec;24(12):1541-50. doi: 10.1038/nbt1266. Nat Biotechnol. 2006. PMID: 17160060 Review.

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