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Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway.
Lee YR, Chen M, Lee JD, Zhang J, Lin SY, Fu TM, Chen H, Ishikawa T, Chiang SY, Katon J, Zhang Y, Shulga YV, Bester AC, Fung J, Monteleone E, Wan L, Shen C, Hsu CH, Papa A, Clohessy JG, Teruya-Feldstein J, Jain S, Wu H, Matesic L, Chen RH, Wei W, Pandolfi PP. Lee YR, et al. Among authors: wan l. Science. 2019 May 17;364(6441):eaau0159. doi: 10.1126/science.aau0159. Science. 2019. PMID: 31097636 Free PMC article.
Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.
Gao D, Wan L, Inuzuka H, Berg AH, Tseng A, Zhai B, Shaik S, Bennett E, Tron AE, Gasser JA, Lau A, Gygi SP, Harper JW, DeCaprio JA, Toker A, Wei W. Gao D, et al. Among authors: wan l. Mol Cell. 2010 Sep 10;39(5):797-808. doi: 10.1016/j.molcel.2010.08.016. Mol Cell. 2010. PMID: 20832730 Free PMC article.
SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction.
Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, Maser RS, Zhai B, Wan L, Gutierrez A, Lau AW, Xiao Y, Christie AL, Aster J, Settleman J, Gygi SP, Kung AL, Look T, Nakayama KI, DePinho RA, Wei W. Inuzuka H, et al. Among authors: wan l. Nature. 2011 Mar 3;471(7336):104-9. doi: 10.1038/nature09732. Nature. 2011. PMID: 21368833 Free PMC article.
Skp2: a novel potential therapeutic target for prostate cancer.
Wang Z, Gao D, Fukushima H, Inuzuka H, Liu P, Wan L, Sarkar FH, Wei W. Wang Z, et al. Among authors: wan l. Biochim Biophys Acta. 2012 Jan;1825(1):11-7. doi: 10.1016/j.bbcan.2011.09.002. Epub 2011 Sep 22. Biochim Biophys Acta. 2012. PMID: 21963805 Free PMC article. Review.
The two faces of FBW7 in cancer drug resistance.
Wang Z, Fukushima H, Gao D, Inuzuka H, Wan L, Lau AW, Liu P, Wei W. Wang Z, et al. Among authors: wan l. Bioessays. 2011 Nov;33(11):851-9. doi: 10.1002/bies.201100101. Epub 2011 Aug 30. Bioessays. 2011. PMID: 22006825 Free PMC article. Review.
Skp2 is a promising therapeutic target in breast cancer.
Wang Z, Fukushima H, Inuzuka H, Wan L, Liu P, Gao D, Sarkar FH, Wei W. Wang Z, et al. Among authors: wan l. Front Oncol. 2012 Jan 4;1(57):57. doi: 10.3389/fonc.2011.00057. Front Oncol. 2012. PMID: 22279619 Free PMC article.
4,237 results