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A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia.
Sri S, Greenstein A, Granata A, Collcutt A, Jochems ACC, McColl BW, Castro BD, Webber C, Reyes CA, Hall C, Lawrence CB, Hawkes C, Pegasiou-Davies CM, Gibson C, Crawford CL, Smith C, Vivien D, McLean FH, Wiseman F, Brezzo G, Lalli G, Pritchard HAT, Markus HS, Bravo-Ferrer I, Taylor J, Leiper J, Berwick J, Gan J, Gallacher J, Moss J, Goense J, McMullan L, Work L, Evans L, Stringer MS, Ashford M, Abulfadl M, Conlon N, Malhotra P, Bath P, Canter R, Brown R, Ince S, Anderle S, Young S, Quick S, Szymkowiak S, Hill S, Allan S, Wang T, Quinn T, Procter T, Farr TD, Zhao X, Yang Z, Hainsworth AH, Wardlaw JM. Sri S, et al. Among authors: wang t. Cereb Circ Cogn Behav. 2023 Oct 11;5:100189. doi: 10.1016/j.cccb.2023.100189. eCollection 2023. Cereb Circ Cogn Behav. 2023. PMID: 37941765 Free PMC article. Review.
Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology.
Horsburgh K, Wardlaw JM, van Agtmael T, Allan SM, Ashford MLJ, Bath PM, Brown R, Berwick J, Cader MZ, Carare RO, Davis JB, Duncombe J, Farr TD, Fowler JH, Goense J, Granata A, Hall CN, Hainsworth AH, Harvey A, Hawkes CA, Joutel A, Kalaria RN, Kehoe PG, Lawrence CB, Lockhart A, Love S, Macleod MR, Macrae IM, Markus HS, McCabe C, McColl BW, Meakin PJ, Miller A, Nedergaard M, O'Sullivan M, Quinn TJ, Rajani R, Saksida LM, Smith C, Smith KJ, Touyz RM, Trueman RC, Wang T, Williams A, Williams SCR, Work LM. Horsburgh K, et al. Among authors: wang t. Clin Sci (Lond). 2018 Apr 30;132(8):851-868. doi: 10.1042/CS20171620. Print 2018 Apr 30. Clin Sci (Lond). 2018. PMID: 29712883 Free PMC article.
Global proteomic analysis of extracellular matrix in mouse and human brain highlights relevance to cerebrovascular disease.
Pokhilko A, Brezzo G, Handunnetthi L, Heilig R, Lennon R, Smith C, Allan SM, Granata A, Sinha S, Wang T, Markus HS, Naba A, Fischer R, Van Agtmael T, Horsburgh K, Cader MZ. Pokhilko A, et al. Among authors: wang t. J Cereb Blood Flow Metab. 2021 Sep;41(9):2423-2438. doi: 10.1177/0271678X211004307. Epub 2021 Mar 17. J Cereb Blood Flow Metab. 2021. PMID: 33730931 Free PMC article.
A novel human iPSC model of COL4A1/A2 small vessel disease unveils a key pathogenic role of matrix metalloproteinases.
Al-Thani M, Goodwin-Trotman M, Bell S, Patel K, Fleming LK, Vilain C, Abramowicz M, Allan SM, Wang T, Cader MZ, Horsburgh K, Van Agtmael T, Sinha S, Markus HS, Granata A. Al-Thani M, et al. Among authors: wang t. Stem Cell Reports. 2023 Dec 12;18(12):2386-2399. doi: 10.1016/j.stemcr.2023.10.014. Epub 2023 Nov 16. Stem Cell Reports. 2023. PMID: 37977146 Free PMC article.
Patient-Specific iPSC Model of a Genetic Vascular Dementia Syndrome Reveals Failure of Mural Cells to Stabilize Capillary Structures.
Kelleher J, Dickinson A, Cain S, Hu Y, Bates N, Harvey A, Ren J, Zhang W, Moreton FC, Muir KW, Ward C, Touyz RM, Sharma P, Xu Q, Kimber SJ, Wang T. Kelleher J, et al. Among authors: wang t. Stem Cell Reports. 2019 Nov 12;13(5):817-831. doi: 10.1016/j.stemcr.2019.10.004. Epub 2019 Oct 31. Stem Cell Reports. 2019. PMID: 31680059 Free PMC article.
Enhanced chondrogenesis from human embryonic stem cells.
Wang T, Nimkingratana P, Smith CA, Cheng A, Hardingham TE, Kimber SJ. Wang T, et al. Stem Cell Res. 2019 Aug;39:101497. doi: 10.1016/j.scr.2019.101497. Epub 2019 Jul 9. Stem Cell Res. 2019. PMID: 31326745 Free PMC article.
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