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STING-activating nanoparticles normalize the vascular-immune interface to potentiate cancer immunotherapy.
Wang-Bishop L, Kimmel BR, Ngwa VM, Madden MZ, Baljon JJ, Florian DC, Hanna A, Pastora LE, Sheehy TL, Kwiatkowski AJ, Wehbe M, Wen X, Becker KW, Garland KM, Schulman JA, Shae D, Edwards D, Wolf MM, Delapp R, Christov PP, Beckermann KE, Balko JM, Rathmell WK, Rathmell JC, Chen J, Wilson JT. Wang-Bishop L, et al. Sci Immunol. 2023 May 12;8(83):eadd1153. doi: 10.1126/sciimmunol.add1153. Epub 2023 May 5. Sci Immunol. 2023. PMID: 37146128
Nanoparticle delivery improves the pharmacokinetic properties of cyclic dinucleotide STING agonists to open a therapeutic window for intravenous administration.
Wehbe M, Wang-Bishop L, Becker KW, Shae D, Baljon JJ, He X, Christov P, Boyd KL, Balko JM, Wilson JT. Wehbe M, et al. Among authors: wang bishop l. J Control Release. 2021 Feb 10;330:1118-1129. doi: 10.1016/j.jconrel.2020.11.017. Epub 2020 Nov 12. J Control Release. 2021. PMID: 33189789 Free PMC article.
Pharmacological Activation of cGAS for Cancer Immunotherapy.
Garland KM, Rosch JC, Carson CS, Wang-Bishop L, Hanna A, Sevimli S, Van Kaer C, Balko JM, Ascano M, Wilson JT. Garland KM, et al. Among authors: wang bishop l. Front Immunol. 2021 Nov 26;12:753472. doi: 10.3389/fimmu.2021.753472. eCollection 2021. Front Immunol. 2021. PMID: 34899704 Free PMC article.
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