Ward WH - Search Results

1

A novel series of non-nucleoside inhibitors of inosine 5'-monophosphate dehydrogenase with immunosuppressive activity.

Franklin TJ, Morris WP, Jacobs VN, Culbert EJ, Heys CA, Ward WH, Cook PN, Jung F, Plé P. Franklin TJ, et al. Among authors: ward wh. Biochem Pharmacol. 1999 Sep 1;58(5):867-76. doi: 10.1016/s0006-2952(99)00170-7. Biochem Pharmacol. 1999. PMID: 10449198

2

Epidermal growth factor receptor tyrosine kinase. Investigation of catalytic mechanism, structure-based searching and discovery of a potent inhibitor.

Ward WH, Cook PN, Slater AM, Davies DH, Holdgate GA, Green LR. Ward WH, et al. Biochem Pharmacol. 1994 Aug 17;48(4):659-66. doi: 10.1016/0006-2952(94)90042-6. Biochem Pharmacol. 1994. PMID: 8080438

3

(2,6-Dimethylphenylsulphonyl)nitromethane: a new structural type of aldose reductase inhibitor which follows biphasic kinetics and uses an allosteric binding site.

Ward WH, Cook PN, Mirrlees DJ, Brittain DR, Preston J, Carey F, Tuffin DP, Howe R. Ward WH, et al. Biochem Pharmacol. 1991 Nov 6;42(11):2115-23. doi: 10.1016/0006-2952(91)90346-7. Biochem Pharmacol. 1991. PMID: 1958230

4

Kinetic characteristics of ZENECA ZD5522, a potent inhibitor of human and bovine lens aldose reductase.

Cook PN, Ward WH, Petrash JM, Mirrlees DJ, Sennitt CM, Carey F, Preston J, Brittain DR, Tuffin DP, Howe R. Cook PN, et al. Among authors: ward wh. Biochem Pharmacol. 1995 Apr 18;49(8):1043-9. doi: 10.1016/0006-2952(95)98499-y. Biochem Pharmacol. 1995. PMID: 7748183

5

Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530.

Green TP, Fennell M, Whittaker R, Curwen J, Jacobs V, Allen J, Logie A, Hargreaves J, Hickinson DM, Wilkinson RW, Elvin P, Boyer B, Carragher N, Plé PA, Bermingham A, Holdgate GA, Ward WH, Hennequin LF, Davies BR, Costello GF. Green TP, et al. Among authors: ward wh. Mol Oncol. 2009 Jun;3(3):248-61. doi: 10.1016/j.molonc.2009.01.002. Epub 2009 Feb 7. Mol Oncol. 2009. PMID: 19393585 Free PMC article.

6

Kinetic characteristics of ICI D1694: a quinazoline antifolate which inhibits thymidylate synthase.

Ward WH, Kimbell R, Jackman AL. Ward WH, et al. Biochem Pharmacol. 1992 May 8;43(9):2029-31. doi: 10.1016/0006-2952(92)90646-z. Biochem Pharmacol. 1992. PMID: 1596289

7

Inhibition of aldose reductase by (2,6-dimethylphenylsulphonyl)nitromethane: possible implications for the nature of an inhibitor binding site and a cause of biphasic kinetics.

Ward WH, Cook PN, Mirrlees DJ, Brittain DR, Preston J, Carey F, Tuffin DP, Howe R. Ward WH, et al. Adv Exp Med Biol. 1993;328:301-11. doi: 10.1007/978-1-4615-2904-0_32. Adv Exp Med Biol. 1993. PMID: 8493907

8

Inhibition of squalene synthase of rat liver by novel 3' substituted quinuclidines.

McTaggart F, Brown GR, Davidson RG, Freeman S, Holdgate GA, Mallion KB, Mirrlees DJ, Smith GJ, Ward WH. McTaggart F, et al. Among authors: ward wh. Biochem Pharmacol. 1996 Jun 14;51(11):1477-87. doi: 10.1016/0006-2952(96)00089-5. Biochem Pharmacol. 1996. PMID: 8630089

9

Inhibition of squalene synthase in vitro by 3-(biphenyl-4-yl)-quinuclidine.

Ward WH, Holdgate GA, Freeman S, McTaggart F, Girdwood PA, Davidson RG, Mallion KB, Brown GR, Eakin MA. Ward WH, et al. Biochem Pharmacol. 1996 Jun 14;51(11):1489-501. doi: 10.1016/0006-2952(96)00090-1. Biochem Pharmacol. 1996. PMID: 8630090

10

Ponalrestat: a potent and specific inhibitor of aldose reductase.

Ward WH, Sennitt CM, Ross H, Dingle A, Timms D, Mirrlees DJ, Tuffin DP. Ward WH, et al. Biochem Pharmacol. 1990 Jan 15;39(2):337-46. doi: 10.1016/0006-2952(90)90033-h. Biochem Pharmacol. 1990. PMID: 2105733

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