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Page 1
Hierarchical tumor heterogeneity mediated by cell contact between distinct genetic subclones.
Karthikeyan S, Waters IG, Dennison L, Chu D, Donaldson J, Shin DH, Rosen DM, Gonzalez-Ericsson PI, Sanchez V, Sanders ME, Pantone MV, Bergman RE, Davidson BA, Reed SC, Zabransky DJ, Cravero K, Kyker-Snowman K, Button B, Wong HY, Hurley PJ, Croessmann S, Park BH. Karthikeyan S, et al. Among authors: waters ig. J Clin Invest. 2021 Mar 15;131(6):e143557. doi: 10.1172/JCI143557. J Clin Invest. 2021. PMID: 33529175 Free PMC article.
NOTCH1 PEST domain variants are responsive to standard of care treatments despite distinct transformative properties in a breast cancer model.
Cravero K, Pantone MV, Shin DH, Bergman R, Cochran R, Chu D, Zabransky DJ, Karthikeyan S, Waters IG, Hunter N, Rosen DM, Kyker-Snowman K, Dalton WB, Button B, Shinn D, Wong HY, Donaldson J, Hurley PJ, Croessmann S, Park BH. Cravero K, et al. Among authors: waters ig. Oncotarget. 2022 Feb 16;13:373-386. doi: 10.18632/oncotarget.28200. eCollection 2022. Oncotarget. 2022. PMID: 35186194 Free PMC article.
TrkA overexpression in non-tumorigenic human breast cell lines confers oncogenic and metastatic properties.
Kyker-Snowman K, Hughes RM, Yankaskas CL, Cravero K, Karthikeyan S, Button B, Waters I, Rosen DM, Dennison L, Hunter N, Donaldson J, Christenson ES, Konstantopoulos K, Hurley PJ, Croessmann S, Park BH. Kyker-Snowman K, et al. Breast Cancer Res Treat. 2020 Feb;179(3):631-642. doi: 10.1007/s10549-019-05506-3. Epub 2019 Dec 10. Breast Cancer Res Treat. 2020. PMID: 31823098 Free PMC article.
The estrogen receptor-alpha S118P variant does not affect breast cancer incidence or response to endocrine therapies.
Button B, Croessmann S, Chu D, Rosen DM, Zabransky DJ, Dalton WB, Cravero K, Kyker-Snowman K, Waters I, Karthikeyan S, Christenson ES, Donaldson J, Hunter T, Dennison L, Ramin C, May B, Roden R, Petry D, Armstrong DK, Visvanathan K, Park BH. Button B, et al. Breast Cancer Res Treat. 2019 Apr;174(2):401-412. doi: 10.1007/s10549-018-05087-7. Epub 2018 Dec 17. Breast Cancer Res Treat. 2019. PMID: 30560461 Free PMC article.
HER2 Reactivation through Acquisition of the HER2 L755S Mutation as a Mechanism of Acquired Resistance to HER2-targeted Therapy in HER2+ Breast Cancer.
Xu X, De Angelis C, Burke KA, Nardone A, Hu H, Qin L, Veeraraghavan J, Sethunath V, Heiser LM, Wang N, Ng CKY, Chen ES, Renwick A, Wang T, Nanda S, Shea M, Mitchell T, Rajendran M, Waters I, Zabransky DJ, Scott KL, Gutierrez C, Nagi C, Geyer FC, Chamness GC, Park BH, Shaw CA, Hilsenbeck SG, Rimawi MF, Gray JW, Weigelt B, Reis-Filho JS, Osborne CK, Schiff R. Xu X, et al. Clin Cancer Res. 2017 Sep 1;23(17):5123-5134. doi: 10.1158/1078-0432.CCR-16-2191. Epub 2017 May 9. Clin Cancer Res. 2017. PMID: 28487443 Free PMC article.
A Polycythemia Vera JAK2 Mutation Masquerading as a Duodenal Cancer Mutation.
Lee J, Axilbund J, Dalton WB, Laheru D, Watkins S, Chu D, Cravero K, Button B, Kyker-Snowman K, Waters I, Gocke CD, Lauring J, Park BH. Lee J, et al. J Natl Compr Canc Netw. 2016 Dec;14(12):1495-1498. doi: 10.6004/jnccn.2016.0161. J Natl Compr Canc Netw. 2016. PMID: 27956534 Free PMC article.
Detection fidelity of AR mutations in plasma derived cell-free DNA.
Goldstein A, Toro PV, Lee J, Silberstein JL, Nakazawa M, Waters I, Cravero K, Chu D, Cochran RL, Kim M, Shinn D, Torquato S, Hughes RM, Pallavajjala A, Carducci MA, Paller CJ, Denmeade SR, Kressel B, Trock BJ, Eisenberger MA, Antonarakis ES, Park BH, Hurley PJ. Goldstein A, et al. Oncotarget. 2017 Feb 28;8(9):15651-15662. doi: 10.18632/oncotarget.14926. Oncotarget. 2017. PMID: 28152506 Free PMC article.
Genetic Alterations Detected in Cell-Free DNA Are Associated With Enzalutamide and Abiraterone Resistance in Castration-Resistant Prostate Cancer.
Torquato S, Pallavajjala A, Goldstein A, Toro PV, Silberstein JL, Lee J, Nakazawa M, Waters I, Chu D, Shinn D, Groginski T, Hughes RM, Simons BW, Khan H, Feng Z, Carducci MA, Paller CJ, Denmeade SR, Kressel B, Eisenberger MA, Antonarakis ES, Trock BJ, Park BH, Hurley PJ. Torquato S, et al. JCO Precis Oncol. 2019;3:PO.18.00227. doi: 10.1200/PO.18.00227. Epub 2019 Apr 3. JCO Precis Oncol. 2019. PMID: 31131348 Free PMC article.
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