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An A13 repeat within the 3'-untranslated region of epidermal growth factor receptor (EGFR) is frequently mutated in microsatellite instability colon cancers and is associated with increased EGFR expression.
Yuan Z, Shin J, Wilson A, Goel S, Ling YH, Ahmed N, Dopeso H, Jhawer M, Nasser S, Montagna C, Fordyce K, Augenlicht LH, Aaltonen LA, Arango D, Weber TK, Mariadason JM. Yuan Z, et al. Among authors: weber tk. Cancer Res. 2009 Oct 1;69(19):7811-8. doi: 10.1158/0008-5472.CAN-09-0986. Epub 2009 Sep 29. Cancer Res. 2009. PMID: 19789347 Free PMC article.
Erlotinib, an effective epidermal growth factor receptor tyrosine kinase inhibitor, induces p27KIP1 up-regulation and nuclear translocation in association with cell growth inhibition and G1/S phase arrest in human non-small-cell lung cancer cell lines.
Ling YH, Li T, Yuan Z, Haigentz M Jr, Weber TK, Perez-Soler R. Ling YH, et al. Among authors: weber tk. Mol Pharmacol. 2007 Aug;72(2):248-58. doi: 10.1124/mol.107.034827. Epub 2007 Apr 24. Mol Pharmacol. 2007. PMID: 17456787 Retracted.
A del T poly T (8) mutation in the 3' untranslated region (UTR) of the CDK2-AP1 gene is functionally significant causing decreased mRNA stability resulting in decreased CDK2-AP1 expression in human microsatellite unstable (MSI) colorectal cancer (CRC).
Shin J, Yuan Z, Fordyce K, Sreeramoju P, Kent TS, Kim J, Wang V, Schneyer D, Weber TK. Shin J, et al. Among authors: weber tk. Surgery. 2007 Aug;142(2):222-7. doi: 10.1016/j.surg.2007.04.002. Surgery. 2007. PMID: 17689689
The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone deacetylase inhibitors (HDACi) in colon cancer cells in a Kruppel-like factor 5 (KLF5)-dependent manner.
Shin J, Carr A, Corner GA, Tögel L, Dávalos-Salas M, Tran H, Chueh AC, Al-Obaidi S, Chionh F, Ahmed N, Buchanan DD, Young JP, Malo MS, Hodin RA, Arango D, Sieber OM, Augenlicht LH, Dhillon AS, Weber TK, Mariadason JM. Shin J, et al. Among authors: weber tk. J Biol Chem. 2014 Sep 5;289(36):25306-16. doi: 10.1074/jbc.M114.557546. Epub 2014 Jul 18. J Biol Chem. 2014. PMID: 25037223 Free PMC article.
69 results