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The CXCR4 inhibitor BL-8040 induces the apoptosis of AML blasts by downregulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression.
Abraham M, Klein S, Bulvik B, Wald H, Weiss ID, Olam D, Weiss L, Beider K, Eizenberg O, Wald O, Galun E, Avigdor A, Benjamini O, Nagler A, Pereg Y, Tavor S, Peled A. Abraham M, et al. Among authors: weiss id, weiss l. Leukemia. 2017 Nov;31(11):2336-2346. doi: 10.1038/leu.2017.82. Epub 2017 Mar 10. Leukemia. 2017. PMID: 28280274
CXCR4 Promotes Neuroblastoma Growth and Therapeutic Resistance through miR-15a/16-1-Mediated ERK and BCL2/Cyclin D1 Pathways.
Klein S, Abraham M, Bulvik B, Dery E, Weiss ID, Barashi N, Abramovitch R, Wald H, Harel Y, Olam D, Weiss L, Beider K, Eizenberg O, Wald O, Galun E, Pereg Y, Peled A. Klein S, et al. Among authors: weiss id, weiss l. Cancer Res. 2018 Mar 15;78(6):1471-1483. doi: 10.1158/0008-5472.CAN-17-0454. Epub 2017 Dec 19. Cancer Res. 2018. PMID: 29259008
The mTOR inhibitor everolimus overcomes CXCR4-mediated resistance to histone deacetylase inhibitor panobinostat through inhibition of p21 and mitotic regulators.
Beider K, Bitner H, Voevoda-Dimenshtein V, Rosenberg E, Sirovsky Y, Magen H, Canaani J, Ostrovsky O, Shilo N, Shimoni A, Abraham M, Weiss L, Milyavsky M, Peled A, Nagler A. Beider K, et al. Among authors: weiss l. Biochem Pharmacol. 2019 Oct;168:412-428. doi: 10.1016/j.bcp.2019.07.016. Epub 2019 Jul 17. Biochem Pharmacol. 2019. PMID: 31325448
Blocking of Transient Receptor Potential Vanilloid 1 (TRPV1) promotes terminal mitophagy in multiple myeloma, disturbing calcium homeostasis and targeting ubiquitin pathway and bortezomib-induced unfolded protein response.
Beider K, Rosenberg E, Dimenshtein-Voevoda V, Sirovsky Y, Vladimirsky J, Magen H, Ostrovsky O, Shimoni A, Bromberg Z, Weiss L, Peled A, Nagler A. Beider K, et al. Among authors: weiss l. J Hematol Oncol. 2020 Nov 25;13(1):158. doi: 10.1186/s13045-020-00993-0. J Hematol Oncol. 2020. PMID: 33239060 Free PMC article.
2,980 results