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Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity.
Ellerby LM, Andrusiak RL, Wellington CL, Hackam AS, Propp SS, Wood JD, Sharp AH, Margolis RL, Ross CA, Salvesen GS, Hayden MR, Bredesen DE. Ellerby LM, et al. Among authors: wellington cl. J Biol Chem. 1999 Mar 26;274(13):8730-6. doi: 10.1074/jbc.274.13.8730. J Biol Chem. 1999. PMID: 10085113 Free article.
Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract.
Wellington CL, Ellerby LM, Hackam AS, Margolis RL, Trifiro MA, Singaraja R, McCutcheon K, Salvesen GS, Propp SS, Bromm M, Rowland KJ, Zhang T, Rasper D, Roy S, Thornberry N, Pinsky L, Kakizuka A, Ross CA, Nicholson DW, Bredesen DE, Hayden MR. Wellington CL, et al. J Biol Chem. 1998 Apr 10;273(15):9158-67. doi: 10.1074/jbc.273.15.9158. J Biol Chem. 1998. PMID: 9535906 Free article.
Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.
Wellington CL, Ellerby LM, Gutekunst CA, Rogers D, Warby S, Graham RK, Loubser O, van Raamsdonk J, Singaraja R, Yang YZ, Gafni J, Bredesen D, Hersch SM, Leavitt BR, Roy S, Nicholson DW, Hayden MR. Wellington CL, et al. J Neurosci. 2002 Sep 15;22(18):7862-72. doi: 10.1523/JNEUROSCI.22-18-07862.2002. J Neurosci. 2002. PMID: 12223539 Free PMC article.
156 results