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An induced pluripotent stem cell model of Fanconi anemia reveals mechanisms of p53-driven progenitor cell differentiation.
Marion W, Boettcher S, Ruiz-Torres S, Lummertz da Rocha E, Lundin V, Morris V, Chou S, Zhao AM, Kubaczka C, Aumais O, Zhang Y, Shimamura A, Schlaeger TM, North TE, Ebert BL, Wells SI, Daley GQ, Rowe RG. Marion W, et al. Among authors: wells si. Blood Adv. 2020 Oct 13;4(19):4679-4692. doi: 10.1182/bloodadvances.2020001593. Blood Adv. 2020. PMID: 33002135 Free PMC article.
The fanconi anemia pathway limits human papillomavirus replication.
Hoskins EE, Morreale RJ, Werner SP, Higginbotham JM, Laimins LA, Lambert PF, Brown DR, Gillison ML, Nuovo GJ, Witte DP, Kim MO, Davies SM, Mehta PA, Butsch Kovacic M, Wikenheiser-Brokamp KA, Wells SI. Hoskins EE, et al. Among authors: wells si. J Virol. 2012 Aug;86(15):8131-8. doi: 10.1128/JVI.00408-12. Epub 2012 May 23. J Virol. 2012. PMID: 22623785 Free PMC article.
High-risk human papillomavirus E6 protein promotes reprogramming of Fanconi anemia patient cells through repression of p53 but does not allow for sustained growth of induced pluripotent stem cells.
Chlon TM, Hoskins EE, Mayhew CN, Wikenheiser-Brokamp KA, Davies SM, Mehta P, Myers KC, Wells JM, Wells SI. Chlon TM, et al. Among authors: wells si, wells jm. J Virol. 2014 Oct;88(19):11315-26. doi: 10.1128/JVI.01533-14. Epub 2014 Jul 16. J Virol. 2014. PMID: 25031356 Free PMC article.
Acquisition of Relative Interstrand Crosslinker Resistance and PARP Inhibitor Sensitivity in Fanconi Anemia Head and Neck Cancers.
Lombardi AJ, Hoskins EE, Foglesong GD, Wikenheiser-Brokamp KA, Wiesmüller L, Hanenberg H, Andreassen PR, Jacobs AJ, Olson SB, Keeble WW, Hays LE, Wells SI. Lombardi AJ, et al. Among authors: wells si. Clin Cancer Res. 2015 Apr 15;21(8):1962-72. doi: 10.1158/1078-0432.CCR-14-2616. Epub 2015 Jan 21. Clin Cancer Res. 2015. PMID: 25609062 Free PMC article.
Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling.
Romick-Rosendale LE, Hoskins EE, Privette Vinnedge LM, Foglesong GD, Brusadelli MG, Potter SS, Komurov K, Brugmann SA, Lambert PF, Kimple RJ, Virts EL, Hanenberg H, Gillison ML, Wells SI. Romick-Rosendale LE, et al. Among authors: wells si. Clin Cancer Res. 2016 Apr 15;22(8):2062-73. doi: 10.1158/1078-0432.CCR-15-2209. Epub 2015 Nov 24. Clin Cancer Res. 2016. PMID: 26603260 Free PMC article.
Overcoming Pluripotent Stem Cell Dependence on the Repair of Endogenous DNA Damage.
Chlon TM, Ruiz-Torres S, Maag L, Mayhew CN, Wikenheiser-Brokamp KA, Davies SM, Mehta P, Myers KC, Wells JM, Wells SI. Chlon TM, et al. Among authors: wells si, wells jm. Stem Cell Reports. 2016 Jan 12;6(1):44-54. doi: 10.1016/j.stemcr.2015.12.001. Stem Cell Reports. 2016. PMID: 26771352 Free PMC article.
Impaired immune function in children and adults with Fanconi anemia.
Myers KC, Sauter S, Zhang X, Bleesing JJ, Davies SM, Wells SI, Mehta PA, Kumar A, Marmer D, Marsh R, Brown D, Butsch Kovacic M. Myers KC, et al. Among authors: wells si. Pediatr Blood Cancer. 2017 Nov;64(11):10.1002/pbc.26599. doi: 10.1002/pbc.26599. Epub 2017 May 30. Pediatr Blood Cancer. 2017. PMID: 28557197 Free PMC article.
81 results