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RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer.
Wolfe AL, Singh K, Zhong Y, Drewe P, Rajasekhar VK, Sanghvi VR, Mavrakis KJ, Jiang M, Roderick JE, Van der Meulen J, Schatz JH, Rodrigo CM, Zhao C, Rondou P, de Stanchina E, Teruya-Feldstein J, Kelliher MA, Speleman F, Porco JA Jr, Pelletier J, Rätsch G, Wendel HG. Wolfe AL, et al. Among authors: wendel hg. Nature. 2014 Sep 4;513(7516):65-70. doi: 10.1038/nature13485. Epub 2014 Jul 27. Nature. 2014. PMID: 25079319 Free PMC article.
Dissecting eIF4E action in tumorigenesis.
Wendel HG, Silva RL, Malina A, Mills JR, Zhu H, Ueda T, Watanabe-Fukunaga R, Fukunaga R, Teruya-Feldstein J, Pelletier J, Lowe SW. Wendel HG, et al. Genes Dev. 2007 Dec 15;21(24):3232-7. doi: 10.1101/gad.1604407. Epub 2007 Nov 30. Genes Dev. 2007. PMID: 18055695 Free PMC article.
mTORC1 promotes survival through translational control of Mcl-1.
Mills JR, Hippo Y, Robert F, Chen SM, Malina A, Lin CJ, Trojahn U, Wendel HG, Charest A, Bronson RT, Kogan SC, Nadon R, Housman DE, Lowe SW, Pelletier J. Mills JR, et al. Among authors: wendel hg. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10853-8. doi: 10.1073/pnas.0804821105. Epub 2008 Jul 29. Proc Natl Acad Sci U S A. 2008. PMID: 18664580 Free PMC article.
Tumorigenic activity and therapeutic inhibition of Rheb GTPase.
Mavrakis KJ, Zhu H, Silva RL, Mills JR, Teruya-Feldstein J, Lowe SW, Tam W, Pelletier J, Wendel HG. Mavrakis KJ, et al. Among authors: wendel hg. Genes Dev. 2008 Aug 15;22(16):2178-88. doi: 10.1101/gad.1690808. Genes Dev. 2008. PMID: 18708578 Free PMC article.
Translational control and cancer therapy.
Mavrakis KJ, Wendel HG. Mavrakis KJ, et al. Among authors: wendel hg. Cell Cycle. 2008 Sep 15;7(18):2791-4. doi: 10.4161/cc.7.18.6683. Epub 2008 Sep 25. Cell Cycle. 2008. PMID: 18787409
Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia.
Mavrakis KJ, Wolfe AL, Oricchio E, Palomero T, de Keersmaecker K, McJunkin K, Zuber J, James T, Khan AA, Leslie CS, Parker JS, Paddison PJ, Tam W, Ferrando A, Wendel HG. Mavrakis KJ, et al. Among authors: wendel hg. Nat Cell Biol. 2010 Apr;12(4):372-9. doi: 10.1038/ncb2037. Epub 2010 Feb 28. Nat Cell Biol. 2010. PMID: 20190740 Free PMC article.
Mouse models of cancer as biological filters for complex genomic data.
Oricchio E, Wolfe AL, Schatz JH, Mavrakis KJ, Wendel HG. Oricchio E, et al. Among authors: wendel hg. Dis Model Mech. 2010 Nov-Dec;3(11-12):701-4. doi: 10.1242/dmm.006296. Epub 2010 Sep 27. Dis Model Mech. 2010. PMID: 20876355 Free PMC article.
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