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Cholangiocyte organoids can repair bile ducts after transplantation in the human liver.
Sampaziotis F, Muraro D, Tysoe OC, Sawiak S, Beach TE, Godfrey EM, Upponi SS, Brevini T, Wesley BT, Garcia-Bernardo J, Mahbubani K, Canu G, Gieseck R 3rd, Berntsen NL, Mulcahy VL, Crick K, Fear C, Robinson S, Swift L, Gambardella L, Bargehr J, Ortmann D, Brown SE, Osnato A, Murphy MP, Corbett G, Gelson WTH, Mells GF, Humphreys P, Davies SE, Amin I, Gibbs P, Sinha S, Teichmann SA, Butler AJ, See TC, Melum E, Watson CJE, Saeb-Parsy K, Vallier L. Sampaziotis F, et al. Among authors: wesley bt. Science. 2021 Feb 19;371(6531):839-846. doi: 10.1126/science.aaz6964. Science. 2021. PMID: 33602855 Free PMC article.
Regional Differences in Human Biliary Tissues and Corresponding In Vitro-Derived Organoids.
Rimland CA, Tilson SG, Morell CM, Tomaz RA, Lu WY, Adams SE, Georgakopoulos N, Otaizo-Carrasquero F, Myers TG, Ferdinand JR, Gieseck RL 3rd, Sampaziotis F, Tysoe OC, Ross A, Kraiczy JM, Wesley B, Muraro D, Zilbauer M, Oniscu GC, Hannan NRF, Forbes SJ, Saeb-Parsy K, Wynn TA, Vallier L. Rimland CA, et al. Hepatology. 2021 Jan;73(1):247-267. doi: 10.1002/hep.31252. Hepatology. 2021. PMID: 32222998 Free PMC article.
Naive Pluripotent Stem Cells Exhibit Phenotypic Variability that Is Driven by Genetic Variation.
Ortmann D, Brown S, Czechanski A, Aydin S, Muraro D, Huang Y, Tomaz RA, Osnato A, Canu G, Wesley BT, Skelly DA, Stegle O, Choi T, Churchill GA, Baker CL, Rugg-Gunn PJ, Munger SC, Reinholdt LG, Vallier L. Ortmann D, et al. Among authors: wesley bt. Cell Stem Cell. 2020 Sep 3;27(3):470-481.e6. doi: 10.1016/j.stem.2020.07.019. Epub 2020 Aug 13. Cell Stem Cell. 2020. PMID: 32795399 Free PMC article.
Single-cell atlas of human liver development reveals pathways directing hepatic cell fates.
Wesley BT, Ross ADB, Muraro D, Miao Z, Saxton S, Tomaz RA, Morell CM, Ridley K, Zacharis ED, Petrus-Reurer S, Kraiczy J, Mahbubani KT, Brown S, Garcia-Bernardo J, Alsinet C, Gaffney D, Horsfall D, Tysoe OC, Botting RA, Stephenson E, Popescu DM, MacParland S, Bader G, McGilvray ID, Ortmann D, Sampaziotis F, Saeb-Parsy K, Haniffa M, Stevens KR, Zilbauer M, Teichmann SA, Vallier L. Wesley BT, et al. Nat Cell Biol. 2022 Oct;24(10):1487-1498. doi: 10.1038/s41556-022-00989-7. Epub 2022 Sep 15. Nat Cell Biol. 2022. PMID: 36109670
Generation of functional hepatocytes by forward programming with nuclear receptors.
Tomaz RA, Zacharis ED, Bachinger F, Wurmser A, Yamamoto D, Petrus-Reurer S, Morell CM, Dziedzicka D, Wesley BT, Geti I, Segeritz CP, de Brito MC, Chhatriwala M, Ortmann D, Saeb-Parsy K, Vallier L. Tomaz RA, et al. Among authors: wesley bt. Elife. 2022 Aug 12;11:e71591. doi: 10.7554/eLife.71591. Elife. 2022. PMID: 35959725 Free PMC article.