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Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions.
Cell Rep. 2022 Feb 1;38(5):110320. doi: 10.1016/j.celrep.2022.110320.
Cell Rep. 2022.
PMID: 35108535
Free PMC article.
New aspects of amino acid metabolism in cancer.
Vettore L, Westbrook RL, Tennant DA.
Vettore L, et al. Among authors: westbrook rl.
Br J Cancer. 2020 Jan;122(2):150-156. doi: 10.1038/s41416-019-0620-5. Epub 2019 Dec 10.
Br J Cancer. 2020.
PMID: 31819187
Free PMC article.
Review.
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Proline metabolism and redox; maintaining a balance in health and disease.
Vettore LA, Westbrook RL, Tennant DA.
Vettore LA, et al. Among authors: westbrook rl.
Amino Acids. 2021 Dec;53(12):1779-1788. doi: 10.1007/s00726-021-03051-2. Epub 2021 Jul 22.
Amino Acids. 2021.
PMID: 34291343
Free PMC article.
Review.
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Prolyl-4-hydroxylase 3 maintains β cell glucose metabolism during fatty acid excess in mice.
Nasteska D, Cuozzo F, Viloria K, Johnson EM, Thakker A, Bany Bakar R, Westbrook RL, Barlow JP, Hoang M, Joseph JW, Lavery GG, Akerman I, Cantley J, Hodson L, Tennant DA, Hodson DJ.
Nasteska D, et al. Among authors: westbrook rl.
JCI Insight. 2021 Aug 23;6(16):e140288. doi: 10.1172/jci.insight.140288.
JCI Insight. 2021.
PMID: 34264866
Free PMC article.
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