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The genetic contribution to severe post-traumatic osteoarthritis.
Valdes AM, Doherty SA, Muir KR, Wheeler M, Maciewicz RA, Zhang W, Doherty M. Valdes AM, et al. Among authors: wheeler m. Ann Rheum Dis. 2013 Oct;72(10):1687-90. doi: 10.1136/annrheumdis-2012-202562. Epub 2013 Jan 26. Ann Rheum Dis. 2013. PMID: 23355107 Free PMC article.
Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis.
Valdes AM, Spector TD, Tamm A, Kisand K, Doherty SA, Dennison EM, Mangino M, Tamm A, Kerna I, Hart DJ, Wheeler M, Cooper C, Lories RJ, Arden NK, Doherty M. Valdes AM, et al. Among authors: wheeler m. Arthritis Rheum. 2010 Aug;62(8):2347-52. doi: 10.1002/art.27530. Arthritis Rheum. 2010. PMID: 20506137 Free article.
The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genome-wide statistical significance.
Valdes AM, Evangelou E, Kerkhof HJ, Tamm A, Doherty SA, Kisand K, Tamm A, Kerna I, Uitterlinden A, Hofman A, Rivadeneira F, Cooper C, Dennison EM, Zhang W, Muir KR, Ioannidis JP, Wheeler M, Maciewicz RA, van Meurs JB, Arden NK, Spector TD, Doherty M. Valdes AM, et al. Among authors: wheeler m. Ann Rheum Dis. 2011 May;70(5):873-5. doi: 10.1136/ard.2010.134155. Epub 2010 Sep 24. Ann Rheum Dis. 2011. PMID: 20870806 Free PMC article. No abstract available.
The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis.
Valdes AM, De Wilde G, Doherty SA, Lories RJ, Vaughn FL, Laslett LL, Maciewicz RA, Soni A, Hart DJ, Zhang W, Muir KR, Dennison EM, Wheeler M, Leaverton P, Cooper C, Spector TD, Cicuttini FM, Chapman V, Jones G, Arden NK, Doherty M. Valdes AM, et al. Among authors: wheeler m. Ann Rheum Dis. 2011 Sep;70(9):1556-61. doi: 10.1136/ard.2010.148122. Epub 2011 May 25. Ann Rheum Dis. 2011. PMID: 21616913 Free PMC article.
Large scale replication study of the association between HLA class II/BTNL2 variants and osteoarthritis of the knee in European-descent populations.
Valdes AM, Styrkarsdottir U, Doherty M, Morris DL, Mangino M, Tamm A, Doherty SA, Kisand K, Kerna I, Tamm A, Wheeler M, Maciewicz RA, Zhang W, Muir KR, Dennison EM, Hart DJ, Metrustry S, Jonsdottir I, Jonsson GF, Jonsson H, Ingvarsson T, Cooper C, Vyse TJ, Spector TD, Stefansson K, Arden NK. Valdes AM, et al. Among authors: wheeler m. PLoS One. 2011;6(8):e23371. doi: 10.1371/journal.pone.0023371. Epub 2011 Aug 10. PLoS One. 2011. PMID: 21853121 Free PMC article.
Genetic contribution to radiographic severity in osteoarthritis of the knee.
Valdes AM, Doherty S, Muir KR, Zhang W, Maciewicz RA, Wheeler M, Arden N, Cooper C, Doherty M. Valdes AM, et al. Among authors: wheeler m. Ann Rheum Dis. 2012 Sep;71(9):1537-40. doi: 10.1136/annrheumdis-2012-201382. Epub 2012 May 21. Ann Rheum Dis. 2012. PMID: 22615457 Free PMC article.
The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: a Mendelian randomisation study.
Panoutsopoulou K, Metrustry S, Doherty SA, Laslett LL, Maciewicz RA, Hart DJ, Zhang W, Muir KR, Wheeler M, Cooper C, Spector TD, Cicuttini FM, Jones G, Arden NK, Doherty M, Zeggini E, Valdes AM; arcOGEN Consortium. Panoutsopoulou K, et al. Among authors: wheeler m. Ann Rheum Dis. 2014 Dec;73(12):2082-6. doi: 10.1136/annrheumdis-2013-203772. Epub 2013 Aug 6. Ann Rheum Dis. 2014. PMID: 23921993 Free PMC article.
Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study.
Panoutsopoulou K, Southam L, Elliott KS, Wrayner N, Zhai G, Beazley C, Thorleifsson G, Arden NK, Carr A, Chapman K, Deloukas P, Doherty M, McCaskie A, Ollier WE, Ralston SH, Spector TD, Valdes AM, Wallis GA, Wilkinson JM, Arden E, Battley K, Blackburn H, Blanco FJ, Bumpstead S, Cupples LA, Day-Williams AG, Dixon K, Doherty SA, Esko T, Evangelou E, Felson D, Gomez-Reino JJ, Gonzalez A, Gordon A, Gwilliam R, Halldorsson BV, Hauksson VB, Hofman A, Hunt SE, Ioannidis JP, Ingvarsson T, Jonsdottir I, Jonsson H, Keen R, Kerkhof HJ, Kloppenburg MG, Koller N, Lakenberg N, Lane NE, Lee AT, Metspalu A, Meulenbelt I, Nevitt MC, O'Neill F, Parimi N, Potter SC, Rego-Perez I, Riancho JA, Sherburn K, Slagboom PE, Stefansson K, Styrkarsdottir U, Sumillera M, Swift D, Thorsteinsdottir U, Tsezou A, Uitterlinden AG, van Meurs JB, Watkins B, Wheeler M, Mitchell S, Zhu Y, Zmuda JM; arcOGEN Consortium; Zeggini E, Loughlin J. Panoutsopoulou K, et al. Among authors: wheeler m. Ann Rheum Dis. 2011 May;70(5):864-7. doi: 10.1136/ard.2010.141473. Epub 2010 Dec 21. Ann Rheum Dis. 2011. PMID: 21177295 Free PMC article.
1,841 results