Wheelhouse RT - Search Results

1

Antitumor imidazotetrazines. 32. Synthesis of novel imidazotetrazinones and related bicyclic heterocycles to probe the mode of action of the antitumor drug temozolomide.

Clark AS, Deans B, Stevens MF, Tisdale MJ, Wheelhouse RT, Denny BJ, Hartley JA. Clark AS, et al. Among authors: wheelhouse rt. J Med Chem. 1995 Apr 28;38(9):1493-504. doi: 10.1021/jm00009a010. J Med Chem. 1995. PMID: 7739008

2

Targeting of tumor cells and DNA by a chlorambucil-spermidine conjugate.

Holley JL, Mather A, Wheelhouse RT, Cullis PM, Hartley JA, Bingham JP, Cohen GM. Holley JL, et al. Among authors: wheelhouse rt. Cancer Res. 1992 Aug 1;52(15):4190-5. Cancer Res. 1992. PMID: 1638533

3

Structural studies on bioactive compounds. Part 27. Chemistry of the immunomodulatory agent bropirimine.

Stevens MF, Baig GU, Gate EN, Wheelhouse RT. Stevens MF, et al. Among authors: wheelhouse rt. Anticancer Drug Des. 1995 Apr;10(3):215-26. Anticancer Drug Des. 1995. PMID: 7748456

4

NMR and molecular modeling investigation of the mechanism of activation of the antitumor drug temozolomide and its interaction with DNA.

Denny BJ, Wheelhouse RT, Stevens MF, Tsang LL, Slack JA. Denny BJ, et al. Among authors: wheelhouse rt. Biochemistry. 1994 Aug 9;33(31):9045-51. doi: 10.1021/bi00197a003. Biochemistry. 1994. PMID: 8049205

5

Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials.

Newlands ES, Stevens MF, Wedge SR, Wheelhouse RT, Brock C. Newlands ES, et al. Among authors: wheelhouse rt. Cancer Treat Rev. 1997 Jan;23(1):35-61. doi: 10.1016/s0305-7372(97)90019-0. Cancer Treat Rev. 1997. PMID: 9189180 Review. No abstract available.

6

Strategy for Imidazotetrazine Prodrugs with Anticancer Activity Independent of MGMT and MMR.

Garelnabi EA, Pletsas D, Li L, Kiakos K, Karodia N, Hartley JA, Phillips RM, Wheelhouse RT. Garelnabi EA, et al. Among authors: wheelhouse rt. ACS Med Chem Lett. 2012 Sep 18;3(12):965-8. doi: 10.1021/ml300132t. eCollection 2012 Dec 13. ACS Med Chem Lett. 2012. PMID: 24900418 Free PMC article.

7

Synthesis and growth-inhibitory activities of imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and heteromethyl groups at the 3-position.

Cousin D, Hummersone MG, Bradshaw TD, Zhang J, Moody CJ, Foreiter MB, Summers HS, Lewis W, Wheelhouse RT, Stevens MFG. Cousin D, et al. Among authors: wheelhouse rt. Medchemcomm. 2018 Jan 19;9(3):545-553. doi: 10.1039/c7md00554g. eCollection 2018 Mar 1. Medchemcomm. 2018. PMID: 30108945 Free PMC article.

8

Antitumour imidazotetrazines: past, present… and future?

Stevens MFG, Wheelhouse RT. Stevens MFG, et al. Among authors: wheelhouse rt. RSC Chem Biol. 2023 Aug 29;4(10):736-741. doi: 10.1039/d3cb00076a. eCollection 2023 Oct 4. RSC Chem Biol. 2023. PMID: 37799580 Free PMC article. Review.

9

Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase.

Shi DF, Wheelhouse RT, Sun D, Hurley LH. Shi DF, et al. Among authors: wheelhouse rt. J Med Chem. 2001 Dec 20;44(26):4509-23. doi: 10.1021/jm010246u. J Med Chem. 2001. PMID: 11741471

10

Polar, functionalized guanine-O6 derivatives resistant to repair by O6-alkylguanine-DNA alkyltransferase: implications for the design of DNA-modifying drugs.

Pletsas D, Wheelhouse RT, Pletsa V, Nicolaou A, Jenkins TC, Bibby MC, Kyrtopoulos SA. Pletsas D, et al. Among authors: wheelhouse rt. Eur J Med Chem. 2006 Mar;41(3):330-9. doi: 10.1016/j.ejmech.2005.11.007. Epub 2006 Feb 3. Eur J Med Chem. 2006. PMID: 16458393

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