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PTPσ inhibitors promote hematopoietic stem cell regeneration.
Zhang Y, Roos M, Himburg H, Termini CM, Quarmyne M, Li M, Zhao L, Kan J, Fang T, Yan X, Pohl K, Diers E, Jin Gim H, Damoiseaux R, Whitelegge J, McBride W, Jung ME, Chute JP. Zhang Y, et al. Among authors: whitelegge j. Nat Commun. 2019 Aug 14;10(1):3667. doi: 10.1038/s41467-019-11490-5. Nat Commun. 2019. PMID: 31413255 Free PMC article.
Small lipidated anti-obesity compounds derived from neuromedin U.
Micewicz ED, Bahattab OS, Willars GB, Waring AJ, Navab M, Whitelegge JP, McBride WH, Ruchala P. Micewicz ED, et al. Among authors: whitelegge jp. Eur J Med Chem. 2015 Aug 28;101:616-26. doi: 10.1016/j.ejmech.2015.07.020. Epub 2015 Jul 14. Eur J Med Chem. 2015. PMID: 26204509 Free PMC article.
Lipid-conjugated Smac analogues.
Micewicz ED, Ratikan JA, Waring AJ, Whitelegge JP, McBride WH, Ruchala P. Micewicz ED, et al. Among authors: whitelegge jp. Bioorg Med Chem Lett. 2015 Oct 15;25(20):4419-27. doi: 10.1016/j.bmcl.2015.09.017. Epub 2015 Sep 8. Bioorg Med Chem Lett. 2015. PMID: 26384289 Free PMC article.
4-(Nitrophenylsulfonyl)piperazines mitigate radiation damage to multiple tissues.
Micewicz ED, Kim K, Iwamoto KS, Ratikan JA, Cheng G, Boxx GM, Damoiseaux RD, Whitelegge JP, Ruchala P, Nguyen C, Purbey P, Loo J, Deng G, Jung ME, Sayre JW, Norris AJ, Schaue D, McBride WH. Micewicz ED, et al. Among authors: whitelegge jp. PLoS One. 2017 Jul 21;12(7):e0181577. doi: 10.1371/journal.pone.0181577. eCollection 2017. PLoS One. 2017. PMID: 28732024 Free PMC article.
ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways.
Le TM, Poddar S, Capri JR, Abt ER, Kim W, Wei L, Uong NT, Cheng CM, Braas D, Nikanjam M, Rix P, Merkurjev D, Zaretsky J, Kornblum HI, Ribas A, Herschman HR, Whitelegge J, Faull KF, Donahue TR, Czernin J, Radu CG. Le TM, et al. Among authors: whitelegge j. Nat Commun. 2017 Aug 14;8(1):241. doi: 10.1038/s41467-017-00221-3. Nat Commun. 2017. PMID: 28808226 Free PMC article.
The Aftermath of Surviving Acute Radiation Hematopoietic Syndrome and its Mitigation.
Micewicz ED, Iwamoto KS, Ratikan JA, Nguyen C, Xie MW, Cheng G, Boxx GM, Deriu E, Damoiseaux RD, Whitelegge JP, Ruchala PP, Avetisyan R, Jung ME, Lawson G, Nemeth E, Ganz T, Sayre JW, McBride WH, Schaue D. Micewicz ED, et al. Radiat Res. 2019 Apr;191(4):323-334. doi: 10.1667/RR15231.1. Epub 2019 Feb 7. Radiat Res. 2019. PMID: 30730284 Free PMC article.
1-(4-nitrobenzenesulfonyl)-4-penylpiperazine increases the number of Peyer's patch-associated regenerating crypts in the small intestines after radiation injury.
Bhat K, Duhachek-Muggy S, Ramanathan R, Saki M, Alli C, Medina P, Damoiseaux R, Whitelegge J, McBride WH, Schaue D, Vlashi E, Pajonk F. Bhat K, et al. Among authors: whitelegge j. Radiother Oncol. 2019 Mar;132:8-15. doi: 10.1016/j.radonc.2018.11.011. Epub 2018 Dec 20. Radiother Oncol. 2019. PMID: 30825974 Free PMC article.
Classes of Drugs that Mitigate Radiation Syndromes.
Micewicz ED, Damoiseaux RD, Deng G, Gomez A, Iwamoto KS, Jung ME, Nguyen C, Norris AJ, Ratikan JA, Ruchala P, Sayre JW, Schaue D, Whitelegge JP, McBride WH. Micewicz ED, et al. Among authors: whitelegge jp. Front Pharmacol. 2021 May 18;12:666776. doi: 10.3389/fphar.2021.666776. eCollection 2021. Front Pharmacol. 2021. PMID: 34084139 Free PMC article.
279 results