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Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk.
Nat Commun. 2020 Jan 16;11(1):307. doi: 10.1038/s41467-019-14187-x.
Nat Commun. 2020.
PMID: 31949142
Free PMC article.
Senescence utilises inflammatory caspases to drive SASP.
Wiggins KA, Clarke MC.
Wiggins KA, et al.
Aging (Albany NY). 2019 Jun 17;11(12):3891-3892. doi: 10.18632/aging.102031.
Aging (Albany NY). 2019.
PMID: 31209185
Free PMC article.
No abstract available.
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IL-1α cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence-associated secretory phenotype.
Wiggins KA, Parry AJ, Cassidy LD, Humphry M, Webster SJ, Goodall JC, Narita M, Clarke MCH.
Wiggins KA, et al.
Aging Cell. 2019 Jun;18(3):e12946. doi: 10.1111/acel.12946. Epub 2019 Mar 27.
Aging Cell. 2019.
PMID: 30916891
Free PMC article.
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The common IL1A single nucleotide polymorphism rs17561 is a hypomorphic mutation that significantly reduces interleukin-1α release from human blood cells.
Wiggins KA, Pyrillou K, Humphry M, Butterworth AS, Clarke MC.
Wiggins KA, et al.
Immunology. 2023 Mar;168(3):459-472. doi: 10.1111/imm.13584. Epub 2022 Oct 13.
Immunology. 2023.
PMID: 36175368
Free article.
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The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin.
Burzynski LC, Humphry M, Pyrillou K, Wiggins KA, Chan JNE, Figg N, Kitt LL, Summers C, Tatham KC, Martin PB, Bennett MR, Clarke MCH.
Burzynski LC, et al. Among authors: wiggins ka.
Immunity. 2019 Apr 16;50(4):1033-1042.e6. doi: 10.1016/j.immuni.2019.03.003. Epub 2019 Mar 26.
Immunity. 2019.
PMID: 30926232
Free PMC article.
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Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance.
Zatreanu D, Robinson HMR, Alkhatib O, Boursier M, Finch H, Geo L, Grande D, Grinkevich V, Heald RA, Langdon S, Majithiya J, McWhirter C, Martin NMB, Moore S, Neves J, Rajendra E, Ranzani M, Schaedler T, Stockley M, Wiggins K, Brough R, Sridhar S, Gulati A, Shao N, Badder LM, Novo D, Knight EG, Marlow R, Haider S, Callen E, Hewitt G, Schimmel J, Prevo R, Alli C, Ferdinand A, Bell C, Blencowe P, Bot C, Calder M, Charles M, Curry J, Ekwuru T, Ewings K, Krajewski W, MacDonald E, McCarron H, Pang L, Pedder C, Rigoreau L, Swarbrick M, Wheatley E, Willis S, Wong AC, Nussenzweig A, Tijsterman M, Tutt A, Boulton SJ, Higgins GS, Pettitt SJ, Smith GCM, Lord CJ.
Zatreanu D, et al.
Nat Commun. 2021 Jun 17;12(1):3636. doi: 10.1038/s41467-021-23463-8.
Nat Commun. 2021.
PMID: 34140467
Free PMC article.
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Th1 cytokines are more effective than Th2 cytokines at licensing anti-tumour functions in CD40-activated human macrophages in vitro.
Luheshi N, Davies G, Poon E, Wiggins K, McCourt M, Legg J.
Luheshi N, et al.
Eur J Immunol. 2014 Jan;44(1):162-72. doi: 10.1002/eji.201343351. Epub 2013 Oct 16.
Eur J Immunol. 2014.
PMID: 24114634
Free article.
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