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Proteogenetic drug response profiling elucidates targetable vulnerabilities of myelofibrosis.
Wildschut MHE, Mena J, Dördelmann C, van Oostrum M, Hale BD, Settelmeier J, Festl Y, Lysenko V, Schürch PM, Ring A, Severin Y, Bader MS, Pedrioli PGA, Goetze S, van Drogen A, Balabanov S, Skoda RC, Lopes M, Wollscheid B, Theocharides APA, Snijder B. Wildschut MHE, et al. Nat Commun. 2023 Oct 12;14(1):6414. doi: 10.1038/s41467-023-42101-z. Nat Commun. 2023. PMID: 37828014 Free PMC article.
Calreticulin mutations affect its chaperone function and perturb the glycoproteome.
Schürch PM, Malinovska L, Hleihil M, Losa M, Hofstetter MC, Wildschut MHE, Lysenko V, Lakkaraju AKK, Maat CA, Benke D, Aguzzi A, Wollscheid B, Picotti P, Theocharides APA. Schürch PM, et al. Among authors: wildschut mhe. Cell Rep. 2022 Nov 22;41(8):111689. doi: 10.1016/j.celrep.2022.111689. Cell Rep. 2022. PMID: 36417879 Free article.
Disruption of CSF-1R signaling inhibits growth of AML with inv(16).
Simonis A, Russkamp NF, Mueller J, Wilk CM, Wildschut MHE, Myburgh R, Wildner-Verhey van Wijk N, Mueller R, Balabanov S, Valk PJM, Theocharides APA, Manz MG. Simonis A, et al. Among authors: wildschut mhe. Blood Adv. 2021 Mar 9;5(5):1273-1277. doi: 10.1182/bloodadvances.2020003125. Blood Adv. 2021. PMID: 33651098 Free PMC article.
Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription.
Struntz NB, Chen A, Deutzmann A, Wilson RM, Stefan E, Evans HL, Ramirez MA, Liang T, Caballero F, Wildschut MHE, Neel DV, Freeman DB, Pop MS, McConkey M, Muller S, Curtin BH, Tseng H, Frombach KR, Butty VL, Levine SS, Feau C, Elmiligy S, Hong JA, Lewis TA, Vetere A, Clemons PA, Malstrom SE, Ebert BL, Lin CY, Felsher DW, Koehler AN. Struntz NB, et al. Among authors: wildschut mhe. Cell Chem Biol. 2019 May 16;26(5):711-723.e14. doi: 10.1016/j.chembiol.2019.02.009. Epub 2019 Mar 14. Cell Chem Biol. 2019. PMID: 30880155 Free article.
Enhanced engraftment of human myelofibrosis stem and progenitor cells in MISTRG mice.
Lysenko V, Wildner-Verhey van Wijk N, Zimmermann K, Weller MC, Bühler M, Wildschut MHE, Schürch P, Fritz C, Wagner U, Calabresi L, Psaila B, Flavell RA, Vannucchi AM, Mead AJ, Wild PJ, Dirnhofer S, Manz MG, Theocharides APA. Lysenko V, et al. Among authors: wildschut mhe. Blood Adv. 2020 Jun 9;4(11):2477-2488. doi: 10.1182/bloodadvances.2019001364. Blood Adv. 2020. PMID: 32502268 Free PMC article.