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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.
Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, Pahor M, Javors MA, Fernandez E, Miller RA. Harrison DE, et al. Among authors: wilkinson je. Nature. 2009 Jul 16;460(7253):392-5. doi: 10.1038/nature08221. Epub 2009 Jul 8. Nature. 2009. PMID: 19587680 Free PMC article.
Acarbose improves health and lifespan in aging HET3 mice.
Harrison DE, Strong R, Alavez S, Astle CM, DiGiovanni J, Fernandez E, Flurkey K, Garratt M, Gelfond JAL, Javors MA, Levi M, Lithgow GJ, Macchiarini F, Nelson JF, Sukoff Rizzo SJ, Slaga TJ, Stearns T, Wilkinson JE, Miller RA. Harrison DE, et al. Among authors: wilkinson je. Aging Cell. 2019 Apr;18(2):e12898. doi: 10.1111/acel.12898. Epub 2019 Jan 27. Aging Cell. 2019. PMID: 30688027 Free PMC article.
Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males.
Harrison DE, Strong R, Allison DB, Ames BN, Astle CM, Atamna H, Fernandez E, Flurkey K, Javors MA, Nadon NL, Nelson JF, Pletcher S, Simpkins JW, Smith D, Wilkinson JE, Miller RA. Harrison DE, et al. Among authors: wilkinson je. Aging Cell. 2014 Apr;13(2):273-82. doi: 10.1111/acel.12170. Epub 2013 Nov 19. Aging Cell. 2014. PMID: 24245565 Free PMC article.
Rapamycin slows aging in mice.
Wilkinson JE, Burmeister L, Brooks SV, Chan CC, Friedline S, Harrison DE, Hejtmancik JF, Nadon N, Strong R, Wood LK, Woodward MA, Miller RA. Wilkinson JE, et al. Aging Cell. 2012 Aug;11(4):675-82. doi: 10.1111/j.1474-9726.2012.00832.x. Epub 2012 Jun 4. Aging Cell. 2012. PMID: 22587563 Free PMC article.
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.
Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R, Fernandez E, Flurkey K, Javors MA, Nelson JF, Orihuela CJ, Pletcher S, Sharp ZD, Sinclair D, Starnes JW, Wilkinson JE, Nadon NL, Strong R. Miller RA, et al. Among authors: wilkinson je. J Gerontol A Biol Sci Med Sci. 2011 Feb;66(2):191-201. doi: 10.1093/gerona/glq178. Epub 2010 Oct 25. J Gerontol A Biol Sci Med Sci. 2011. PMID: 20974732 Free PMC article.
Host response during unresolved urinary tract infection alters female mammary tissue homeostasis through collagen deposition and TIMP1.
Henry S, Lewis SM, Cyrill SL, Callaway MK, Chatterjee D, Hanasoge Somasundara AV, Jones G, He XY, Caligiuri G, Ciccone MF, Diaz IA, Biswas AA, Hernandez E, Ha T, Wilkinson JE, Egeblad M, Tuveson DA, Dos Santos CO. Henry S, et al. Among authors: wilkinson je. Nat Commun. 2024 Apr 16;15(1):3282. doi: 10.1038/s41467-024-47462-7. Nat Commun. 2024. PMID: 38627380 Free PMC article.
228 results