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Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis.
Mercer AE, Regan SL, Hirst CM, Graham EE, Antoine DJ, Benson CA, Williams DP, Foster J, Kenna JG, Park BK. Mercer AE, et al. Among authors: williams dp. Toxicol Appl Pharmacol. 2009 Sep 15;239(3):297-305. doi: 10.1016/j.taap.2009.05.027. Epub 2009 Jun 10. Toxicol Appl Pharmacol. 2009. PMID: 19523481
RETRACTED: Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity.
Antoine DJ, Jenkins RE, Dear JW, Williams DP, McGill MR, Sharpe MR, Craig DG, Simpson KJ, Jaeschke H, Park BK. Antoine DJ, et al. Among authors: williams dp. J Hepatol. 2012 May;56(5):1070-1079. doi: 10.1016/j.jhep.2011.12.019. Epub 2012 Jan 17. J Hepatol. 2012. PMID: 22266604 Free PMC article. Retracted.
Role of reactive metabolites in drug-induced hepatotoxicity.
Srivastava A, Maggs JL, Antoine DJ, Williams DP, Smith DA, Park BK. Srivastava A, et al. Among authors: williams dp. Handb Exp Pharmacol. 2010;(196):165-94. doi: 10.1007/978-3-642-00663-0_7. Handb Exp Pharmacol. 2010. PMID: 20020263 Review.
The role of metabolic activation in drug-induced hepatotoxicity.
Park BK, Kitteringham NR, Maggs JL, Pirmohamed M, Williams DP. Park BK, et al. Among authors: williams dp. Annu Rev Pharmacol Toxicol. 2005;45:177-202. doi: 10.1146/annurev.pharmtox.45.120403.100058. Annu Rev Pharmacol Toxicol. 2005. PMID: 15822174 Review.
207 results