Wiltshire T - Search Results

1

Functional characterization of 84 PALB2 variants of uncertain significance.

Wiltshire T, Ducy M, Foo TK, Hu C, Lee KY, Belur Nagaraj A, Rodrigue A, Gomes TT, Simard J, Monteiro ANA, Xia B, Carvalho MA, Masson JY, Couch FJ. Wiltshire T, et al. Genet Med. 2020 Mar;22(3):622-632. doi: 10.1038/s41436-019-0682-z. Epub 2019 Oct 21. Genet Med. 2020. PMID: 31636395 Free PMC article.

2

Molecular basis for the association of microcephalin (MCPH1) protein with the cell division cycle protein 27 (Cdc27) subunit of the anaphase-promoting complex.

Singh N, Wiltshire TD, Thompson JR, Mer G, Couch FJ. Singh N, et al. J Biol Chem. 2012 Jan 20;287(4):2854-62. doi: 10.1074/jbc.M111.307868. Epub 2011 Dec 2. J Biol Chem. 2012. PMID: 22139841 Free PMC article.

3

Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1.

Singh N, Basnet H, Wiltshire TD, Mohammad DH, Thompson JR, Héroux A, Botuyan MV, Yaffe MB, Couch FJ, Rosenfeld MG, Mer G. Singh N, et al. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14381-6. doi: 10.1073/pnas.1212366109. Epub 2012 Aug 20. Proc Natl Acad Sci U S A. 2012. PMID: 22908299 Free PMC article.

4

Integrated Genomic Analysis of Pancreatic Ductal Adenocarcinomas Reveals Genomic Rearrangement Events as Significant Drivers of Disease.

Murphy SJ, Hart SN, Halling GC, Johnson SH, Smadbeck JB, Drucker T, Lima JF, Rohakhtar FR, Harris FR, Kosari F, Subramanian S, Petersen GM, Wiltshire TD, Kipp BR, Truty MJ, McWilliams RR, Couch FJ, Vasmatzis G. Murphy SJ, et al. Among authors: wiltshire td. Cancer Res. 2016 Feb 1;76(3):749-61. doi: 10.1158/0008-5472.CAN-15-2198. Epub 2015 Dec 16. Cancer Res. 2016. PMID: 26676757 Free PMC article.

5

Sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair.

Wiltshire TD, Lovejoy CA, Wang T, Xia F, O'Connor MJ, Cortez D. Wiltshire TD, et al. J Biol Chem. 2010 May 7;285(19):14565-71. doi: 10.1074/jbc.M110.104745. Epub 2010 Mar 15. J Biol Chem. 2010. PMID: 20233726 Free PMC article.

6

ATM-dependent CHK2 activation induced by anticancer agent, irofulven.

Wang J, Wiltshire T, Wang Y, Mikell C, Burks J, Cunningham C, Van Laar ES, Waters SJ, Reed E, Wang W. Wang J, et al. Among authors: wiltshire t. J Biol Chem. 2004 Sep 17;279(38):39584-92. doi: 10.1074/jbc.M400015200. Epub 2004 Jul 20. J Biol Chem. 2004. PMID: 15269203 Free article.

7

BRCA1 contributes to cell cycle arrest and chemoresistance in response to the anticancer agent irofulven.

Wiltshire T, Senft J, Wang Y, Konat GW, Wenger SL, Reed E, Wang W. Wiltshire T, et al. Mol Pharmacol. 2007 Apr;71(4):1051-60. doi: 10.1124/mol.106.029504. Epub 2007 Jan 17. Mol Pharmacol. 2007. PMID: 17229870

8

Irofulven induces replication-dependent CHK2 activation related to p53 status.

Wang Y, Wiltshire T, Senft J, Reed E, Wang W. Wang Y, et al. Among authors: wiltshire t. Biochem Pharmacol. 2007 Feb 15;73(4):469-80. doi: 10.1016/j.bcp.2006.10.023. Epub 2006 Oct 27. Biochem Pharmacol. 2007. PMID: 17118344 Free PMC article.

9

Fanconi anemia D2 protein confers chemoresistance in response to the anticancer agent, irofulven.

Wang Y, Wiltshire T, Senft J, Wenger SL, Reed E, Wang W. Wang Y, et al. Among authors: wiltshire t. Mol Cancer Ther. 2006 Dec;5(12):3153-61. doi: 10.1158/1535-7163.MCT-06-0427. Mol Cancer Ther. 2006. PMID: 17172419

10

Model-Based Prediction of Irinotecan-Induced Grade 4 Neutropenia in Cancer Patients: Influence of Incorporating Germline Genetic Factors in the Model.

Karas S, Mathijssen RHJ, van Schaik RHN, Forrest A, Wiltshire T, Bies RR, Innocenti F. Karas S, et al. Among authors: wiltshire t. Clin Pharmacol Ther. 2024 May;115(5):1162-1174. doi: 10.1002/cpt.3190. Epub 2024 Feb 12. Clin Pharmacol Ther. 2024. PMID: 38344867

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