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The mRNA-binding protein HuR promotes hypoxia-induced chemoresistance through posttranscriptional regulation of the proto-oncogene PIM1 in pancreatic cancer cells.
Blanco FF, Jimbo M, Wulfkuhle J, Gallagher I, Deng J, Enyenihi L, Meisner-Kober N, Londin E, Rigoutsos I, Sawicki JA, Risbud MV, Witkiewicz AK, McCue PA, Jiang W, Rui H, Yeo CJ, Petricoin E, Winter JM, Brody JR. Blanco FF, et al. Among authors: witkiewicz ak. Oncogene. 2016 May;35(19):2529-41. doi: 10.1038/onc.2015.325. Epub 2015 Sep 21. Oncogene. 2016. PMID: 26387536 Free PMC article.
Mitoxantrone targets human ubiquitin-specific peptidase 11 (USP11) and is a potent inhibitor of pancreatic cancer cell survival.
Burkhart RA, Peng Y, Norris ZA, Tholey RM, Talbott VA, Liang Q, Ai Y, Miller K, Lal S, Cozzitorto JA, Witkiewicz AK, Yeo CJ, Gehrmann M, Napper A, Winter JM, Sawicki JA, Zhuang Z, Brody JR. Burkhart RA, et al. Among authors: witkiewicz ak. Mol Cancer Res. 2013 Aug;11(8):901-11. doi: 10.1158/1541-7786.MCR-12-0699. Epub 2013 May 21. Mol Cancer Res. 2013. PMID: 23696131
dCK expression correlates with 5-fluorouracil efficacy and HuR cytoplasmic expression in pancreatic cancer: a dual-institutional follow-up with the RTOG 9704 trial.
McAllister F, Pineda DM, Jimbo M, Lal S, Burkhart RA, Moughan J, Winter KA, Abdelmohsen K, Gorospe M, Acosta Ade J, Lankapalli RH, Winter JM, Yeo CJ, Witkiewicz AK, Iacobuzio-Donahue CA, Laheru D, Brody JR. McAllister F, et al. Among authors: witkiewicz ak. Cancer Biol Ther. 2014 Jun 1;15(6):688-98. doi: 10.4161/cbt.28413. Epub 2014 Mar 11. Cancer Biol Ther. 2014. PMID: 24618665 Free PMC article.
HuR's post-transcriptional regulation of Death Receptor 5 in pancreatic cancer cells.
Pineda DM, Rittenhouse DW, Valley CC, Cozzitorto JA, Burkhart RA, Leiby B, Winter JM, Weber MC, Londin ER, Rigoutsos I, Yeo CJ, Gorospe M, Witkiewicz AK, Sachs JN, Brody JR. Pineda DM, et al. Among authors: witkiewicz ak. Cancer Biol Ther. 2012 Aug;13(10):946-55. doi: 10.4161/cbt.20952. Epub 2012 Aug 1. Cancer Biol Ther. 2012. PMID: 22785201 Free PMC article.
Senescent CAFs Mediate Immunosuppression and Drive Breast Cancer Progression.
Ye J, Baer JM, Faget DV, Morikis VA, Ren Q, Melam A, Delgado AP, Luo X, Mullick Bagchi S, Belle JI, Campos E, Friedman M, Veis DJ, Knudsen ES, Witkiewicz AK, Powers S, Longmore GD, DeNardo DG, Stewart SA. Ye J, et al. Among authors: witkiewicz ak. Cancer Discov. 2024 Apr 17:OF1-OF22. doi: 10.1158/2159-8290.CD-23-0426. Online ahead of print. Cancer Discov. 2024. PMID: 38683543
Senescent CAFs mediate immunosuppression and drive breast cancer progression.
Ye J, Baer JM, Faget DV, Morikis VA, Ren Q, Melam A, Delgado AP, Luo X, Mullick Bagchi S, Belle JI, Campos E, Friedman M, Veis DJ, Knudsen ES, Witkiewicz AK, Powers S, Longmore GD, DeNardo DG, Stewart SA. Ye J, et al. Among authors: witkiewicz ak. Cancer Discov. 2024 Apr 29. doi: 10.1158/2159-8290.CD-23-0426. Online ahead of print. Cancer Discov. 2024. PMID: 38683161
154 results