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Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein.
Rodina A, Patel PD, Kang Y, Patel Y, Baaklini I, Wong MJ, Taldone T, Yan P, Yang C, Maharaj R, Gozman A, Patel MR, Patel HJ, Chirico W, Erdjument-Bromage H, Talele TT, Young JC, Chiosis G. Rodina A, et al. Among authors: wong mj. Chem Biol. 2013 Dec 19;20(12):1469-80. doi: 10.1016/j.chembiol.2013.10.008. Epub 2013 Nov 14. Chem Biol. 2013. PMID: 24239008 Free PMC article.
Functional divergence between co-chaperones of Hsc70.
Tzankov S, Wong MJ, Shi K, Nassif C, Young JC. Tzankov S, et al. Among authors: wong mj. J Biol Chem. 2008 Oct 3;283(40):27100-9. doi: 10.1074/jbc.M803923200. Epub 2008 Aug 6. J Biol Chem. 2008. PMID: 18684711 Free PMC article.
Hsp40 chaperones promote degradation of the HERG potassium channel.
Walker VE, Wong MJ, Atanasiu R, Hantouche C, Young JC, Shrier A. Walker VE, et al. Among authors: wong mj. J Biol Chem. 2010 Jan 29;285(5):3319-29. doi: 10.1074/jbc.M109.024000. Epub 2009 Nov 25. J Biol Chem. 2010. PMID: 19940115 Free PMC article.
Hsp70 and DNAJA2 limit CFTR levels through degradation.
Kim Chiaw P, Hantouche C, Wong MJH, Matthes E, Robert R, Hanrahan JW, Shrier A, Young JC. Kim Chiaw P, et al. PLoS One. 2019 Aug 13;14(8):e0220984. doi: 10.1371/journal.pone.0220984. eCollection 2019. PLoS One. 2019. PMID: 31408507 Free PMC article.
77 results