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Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila.
Bjedov I, Cochemé HM, Foley A, Wieser D, Woodling NS, Castillo-Quan JI, Norvaisas P, Lujan C, Regan JC, Toivonen JM, Murphy MP, Thornton J, Kinghorn KJ, Neufeld TP, Cabreiro F, Partridge L. Bjedov I, et al. Among authors: woodling ns. PLoS Genet. 2020 Nov 30;16(11):e1009083. doi: 10.1371/journal.pgen.1009083. eCollection 2020 Nov. PLoS Genet. 2020. PMID: 33253201 Free PMC article.
A Drosophila Model of Neuronopathic Gaucher Disease Demonstrates Lysosomal-Autophagic Defects and Altered mTOR Signalling and Is Functionally Rescued by Rapamycin.
Kinghorn KJ, Grönke S, Castillo-Quan JI, Woodling NS, Li L, Sirka E, Gegg M, Mills K, Hardy J, Bjedov I, Partridge L. Kinghorn KJ, et al. Among authors: woodling ns. J Neurosci. 2016 Nov 16;36(46):11654-11670. doi: 10.1523/JNEUROSCI.4527-15.2016. J Neurosci. 2016. PMID: 27852774 Free PMC article.
The neuronal receptor tyrosine kinase Alk is a target for longevity.
Woodling NS, Aleyakpo B, Dyson MC, Minkley LJ, Rajasingam A, Dobson AJ, Leung KHC, Pomposova S, Fuentealba M, Alic N, Partridge L. Woodling NS, et al. Aging Cell. 2020 May;19(5):e13137. doi: 10.1111/acel.13137. Epub 2020 Apr 15. Aging Cell. 2020. PMID: 32291952 Free PMC article.
Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration.
Mizielinska S, Ridler CE, Balendra R, Thoeng A, Woodling NS, Grässer FA, Plagnol V, Lashley T, Partridge L, Isaacs AM. Mizielinska S, et al. Among authors: woodling ns. Acta Neuropathol Commun. 2017 Apr 18;5(1):29. doi: 10.1186/s40478-017-0432-x. Acta Neuropathol Commun. 2017. PMID: 28420437 Free PMC article.
G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo.
Simone R, Balendra R, Moens TG, Preza E, Wilson KM, Heslegrave A, Woodling NS, Niccoli T, Gilbert-Jaramillo J, Abdelkarim S, Clayton EL, Clarke M, Konrad MT, Nicoll AJ, Mitchell JS, Calvo A, Chio A, Houlden H, Polke JM, Ismail MA, Stephens CE, Vo T, Farahat AA, Wilson WD, Boykin DW, Zetterberg H, Partridge L, Wray S, Parkinson G, Neidle S, Patani R, Fratta P, Isaacs AM. Simone R, et al. Among authors: woodling ns. EMBO Mol Med. 2018 Jan;10(1):22-31. doi: 10.15252/emmm.201707850. EMBO Mol Med. 2018. PMID: 29113975 Free PMC article.
29 results