Wu H - Search Results

1

Characterization of a tumor-associated activating mutation of the p110β PI 3-kinase.

Dbouk HA, Khalil BD, Wu H, Shymanets A, Nürnberg B, Backer JM. Dbouk HA, et al. Among authors: wu h. PLoS One. 2013 May 29;8(5):e63833. doi: 10.1371/journal.pone.0063833. Print 2013. PLoS One. 2013. PMID: 23734178 Free PMC article.

2

Regulation of class IA PI3Ks.

Wu H, Yan Y, Backer JM. Wu H, et al. Biochem Soc Trans. 2007 Apr;35(Pt 2):242-4. doi: 10.1042/BST0350242. Biochem Soc Trans. 2007. PMID: 17371249

3

The iSH2 domain of PI 3-kinase is a rigid tether for p110 and not a conformational switch.

Fu Z, Aronoff-Spencer E, Wu H, Gerfen GJ, Backer JM. Fu Z, et al. Among authors: wu h. Arch Biochem Biophys. 2004 Dec 15;432(2):244-51. doi: 10.1016/j.abb.2004.09.032. Arch Biochem Biophys. 2004. PMID: 15542063 Free PMC article.

4

YXXM motifs in the PDGF-beta receptor serve dual roles as phosphoinositide 3-kinase binding motifs and tyrosine-based endocytic sorting signals.

Wu H, Windmiller DA, Wang L, Backer JM. Wu H, et al. J Biol Chem. 2003 Oct 17;278(42):40425-8. doi: 10.1074/jbc.C300225200. Epub 2003 Aug 25. J Biol Chem. 2003. PMID: 12941951 Free article.

5

Over-expression of the p110beta but not p110alpha isoform of PI 3-kinase inhibits motility in breast cancer cells.

Yip SC, El-Sibai M, Hill KM, Wu H, Fu Z, Condeelis JS, Backer JM. Yip SC, et al. Among authors: wu h. Cell Motil Cytoskeleton. 2004 Nov;59(3):180-8. doi: 10.1002/cm.20032. Cell Motil Cytoskeleton. 2004. PMID: 15468162

6

Mechanism of constitutive phosphoinositide 3-kinase activation by oncogenic mutants of the p85 regulatory subunit.

Shekar SC, Wu H, Fu Z, Yip SC, Nagajyothi, Cahill SM, Girvin ME, Backer JM. Shekar SC, et al. Among authors: wu h. J Biol Chem. 2005 Jul 29;280(30):27850-5. doi: 10.1074/jbc.M506005200. Epub 2005 Jun 2. J Biol Chem. 2005. PMID: 15932879 Free article.

7

Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase.

Pang H, Flinn R, Patsialou A, Wyckoff J, Roussos ET, Wu H, Pozzuto M, Goswami S, Condeelis JS, Bresnick AR, Segall JE, Backer JM. Pang H, et al. Among authors: wu h. Cancer Res. 2009 Dec 1;69(23):8868-76. doi: 10.1158/0008-5472.CAN-09-1968. Epub 2009 Nov 10. Cancer Res. 2009. PMID: 19903845 Free PMC article.

8

Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110alpha and are disrupted in oncogenic p85 mutants.

Wu H, Shekar SC, Flinn RJ, El-Sibai M, Jaiswal BS, Sen KI, Janakiraman V, Seshagiri S, Gerfen GJ, Girvin ME, Backer JM. Wu H, et al. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20258-63. doi: 10.1073/pnas.0902369106. Epub 2009 Nov 13. Proc Natl Acad Sci U S A. 2009. PMID: 19915146 Free PMC article.

9

The structure of p85ni in class IA phosphoinositide 3-kinase exhibits interdomain disorder.

Sen KI, Wu H, Backer JM, Gerfen GJ. Sen KI, et al. Among authors: wu h. Biochemistry. 2010 Mar 16;49(10):2159-66. doi: 10.1021/bi902171d. Biochemistry. 2010. PMID: 20131869 Free PMC article.

10

Assembly and Molecular Architecture of the Phosphoinositide 3-Kinase p85α Homodimer.

LoPiccolo J, Kim SJ, Shi Y, Wu B, Wu H, Chait BT, Singer RH, Sali A, Brenowitz M, Bresnick AR, Backer JM. LoPiccolo J, et al. Among authors: wu h, wu b. J Biol Chem. 2015 Dec 18;290(51):30390-405. doi: 10.1074/jbc.M115.689604. Epub 2015 Oct 16. J Biol Chem. 2015. PMID: 26475863 Free PMC article.

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