Wu J - Search Results

1

Protein Expression and Functional Relevance of Efflux and Uptake Drug Transporters at the Blood-Brain Barrier of Human Brain and Glioblastoma.

Bao X, Wu J, Xie Y, Kim S, Michelhaugh S, Jiang J, Mittal S, Sanai N, Li J. Bao X, et al. Among authors: wu j. Clin Pharmacol Ther. 2020 May;107(5):1116-1127. doi: 10.1002/cpt.1710. Epub 2019 Dec 10. Clin Pharmacol Ther. 2020. PMID: 31664714 Free PMC article.

2

Quantitative and Mechanistic Understanding of AZD1775 Penetration across Human Blood-Brain Barrier in Glioblastoma Patients Using an IVIVE-PBPK Modeling Approach.

Li J, Wu J, Bao X, Honea N, Xie Y, Kim S, Sparreboom A, Sanai N. Li J, et al. Among authors: wu j. Clin Cancer Res. 2017 Dec 15;23(24):7454-7466. doi: 10.1158/1078-0432.CCR-17-0983. Epub 2017 Sep 19. Clin Cancer Res. 2017. PMID: 28928160 Free PMC article. Clinical Trial.

3

Pharmacometabolomics Reveals Irinotecan Mechanism of Action in Cancer Patients.

Bao X, Wu J, Kim S, LoRusso P, Li J. Bao X, et al. Among authors: wu j. J Clin Pharmacol. 2019 Jan;59(1):20-34. doi: 10.1002/jcph.1275. Epub 2018 Jul 27. J Clin Pharmacol. 2019. PMID: 30052267 Free PMC article. Clinical Trial.

4

Physiologically Based Pharmacokinetic Modeling of Central Nervous System Pharmacokinetics of CDK4/6 Inhibitors to Guide Selection of Drug and Dosing Regimen for Brain Cancer Treatment.

Li J, Jiang J, Wu J, Bao X, Sanai N. Li J, et al. Among authors: wu j. Clin Pharmacol Ther. 2021 Feb;109(2):494-506. doi: 10.1002/cpt.2021. Epub 2020 Sep 14. Clin Pharmacol Ther. 2021. PMID: 32799335 Free PMC article.

5

Quantitative protein expression of blood-brain barrier transporters in the vasculature of brain metastases of patients with lung and breast cancer.

Bao X, Wu J, Jiang J, Tien AC, Sanai N, Li J. Bao X, et al. Among authors: wu j. Clin Transl Sci. 2021 Jul;14(4):1265-1271. doi: 10.1111/cts.12978. Epub 2021 Feb 10. Clin Transl Sci. 2021. PMID: 33566445 Free PMC article.

6

An aqueous normal-phase chromatography coupled with tandem mass spectrometry method for determining unbound brain-to-plasma concentration ratio of AZD1775, a Wee1 kinase inhibitor, in patients with glioblastoma.

Wu J, Sanai N, Bao X, LoRusso P, Li J. Wu J, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Aug 15;1028:25-32. doi: 10.1016/j.jchromb.2016.05.050. Epub 2016 Jun 3. J Chromatogr B Analyt Technol Biomed Life Sci. 2016. PMID: 27318641 Free PMC article. Clinical Trial.

7

A liquid chromatography with tandem mass spectrometry method for quantitating total and unbound ceritinib in patient plasma and brain tumor.

Bao X, Wu J, Sanai N, Li J. Bao X, et al. Among authors: wu j. J Pharm Anal. 2018 Feb;8(1):20-26. doi: 10.1016/j.jpha.2017.07.007. Epub 2017 Jul 14. J Pharm Anal. 2018. PMID: 29568664 Free PMC article.

8

Phase 0 Trial of AZD1775 in First-Recurrence Glioblastoma Patients.

Sanai N, Li J, Boerner J, Stark K, Wu J, Kim S, Derogatis A, Mehta S, Dhruv HD, Heilbrun LK, Berens ME, LoRusso PM. Sanai N, et al. Among authors: wu j. Clin Cancer Res. 2018 Aug 15;24(16):3820-3828. doi: 10.1158/1078-0432.CCR-17-3348. Epub 2018 May 24. Clin Cancer Res. 2018. PMID: 29798906 Free PMC article. Clinical Trial.

9

Determination of total and unbound ribociclib in human plasma and brain tumor tissues using liquid chromatography coupled with tandem mass spectrometry.

Bao X, Wu J, Sanai N, Li J. Bao X, et al. Among authors: wu j. J Pharm Biomed Anal. 2019 Mar 20;166:197-204. doi: 10.1016/j.jpba.2019.01.017. Epub 2019 Jan 11. J Pharm Biomed Anal. 2019. PMID: 30660034 Free PMC article.

10

Integrating Dynamic Positron Emission Tomography and Conventional Pharmacokinetic Studies to Delineate Plasma and Tumor Pharmacokinetics of FAU, a Prodrug Bioactivated by Thymidylate Synthase.

Li J, Kim S, Shields AF, Douglas KA, McHugh CI, Lawhorn-Crews JM, Wu J, Mangner TJ, LoRusso PM. Li J, et al. Among authors: wu j. J Clin Pharmacol. 2016 Nov;56(11):1433-1447. doi: 10.1002/jcph.751. J Clin Pharmacol. 2016. PMID: 27095537 Free PMC article. Clinical Trial.

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