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Page 1
Inhibiting phosphoglycerate dehydrogenase counteracts chemotherapeutic efficacy against MYCN-amplified neuroblastoma.
Int J Cancer. 2021 Mar 1;148(5):1219-1232. doi: 10.1002/ijc.33423. Epub 2020 Dec 17.
Int J Cancer. 2021.
PMID: 33284994
Free article.
Inhibiting PHGDH with NCT-503 reroutes glucose-derived carbons into the TCA cycle, independently of its on-target effect.
Arlt B, Mastrobuoni G, Wuenschel J, Astrahantseff K, Eggert A, Kempa S, Deubzer HE.
Arlt B, et al. Among authors: wuenschel j.
J Enzyme Inhib Med Chem. 2021 Dec;36(1):1282-1289. doi: 10.1080/14756366.2021.1935917.
J Enzyme Inhib Med Chem. 2021.
PMID: 34192988
Free PMC article.
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Neuroblastoma cells depend on HDAC11 for mitotic cell cycle progression and survival.
Thole TM, Lodrini M, Fabian J, Wuenschel J, Pfeil S, Hielscher T, Kopp-Schneider A, Heinicke U, Fulda S, Witt O, Eggert A, Fischer M, Deubzer HE.
Thole TM, et al. Among authors: wuenschel j.
Cell Death Dis. 2017 Mar 2;8(3):e2635. doi: 10.1038/cddis.2017.49.
Cell Death Dis. 2017.
PMID: 28252645
Free PMC article.
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