Wulff H - Search Results

1

Early changes in cerebellar physiology accompany motor dysfunction in the polyglutamine disease spinocerebellar ataxia type 3.

Shakkottai VG, do Carmo Costa M, Dell'Orco JM, Sankaranarayanan A, Wulff H, Paulson HL. Shakkottai VG, et al. Among authors: wulff h. J Neurosci. 2011 Sep 7;31(36):13002-14. doi: 10.1523/JNEUROSCI.2789-11.2011. J Neurosci. 2011. PMID: 21900579 Free PMC article.

2

Neuronal Atrophy Early in Degenerative Ataxia Is a Compensatory Mechanism to Regulate Membrane Excitability.

Dell'Orco JM, Wasserman AH, Chopra R, Ingram MA, Hu YS, Singh V, Wulff H, Opal P, Orr HT, Shakkottai VG. Dell'Orco JM, et al. Among authors: wulff h. J Neurosci. 2015 Aug 12;35(32):11292-307. doi: 10.1523/JNEUROSCI.1357-15.2015. J Neurosci. 2015. PMID: 26269637 Free PMC article.

3

Alterations in cerebellar physiology are associated with a stiff-legged gait in Atcay(ji-hes) mice.

Luna-Cancalon K, Sikora KM, Pappas SS, Singh V, Wulff H, Paulson HL, Burmeister M, Shakkottai VG. Luna-Cancalon K, et al. Among authors: wulff h. Neurobiol Dis. 2014 Jul;67:140-8. doi: 10.1016/j.nbd.2014.03.020. Epub 2014 Apr 12. Neurobiol Dis. 2014. PMID: 24727095 Free PMC article.

4

Targeting potassium channels to treat cerebellar ataxia.

Bushart DD, Chopra R, Singh V, Murphy GG, Wulff H, Shakkottai VG. Bushart DD, et al. Among authors: wulff h. Ann Clin Transl Neurol. 2018 Jan 22;5(3):297-314. doi: 10.1002/acn3.527. eCollection 2018 Mar. Ann Clin Transl Neurol. 2018. PMID: 29560375 Free PMC article.

5

Discovery of Novel Activators of Large-Conductance Calcium-Activated Potassium Channels for the Treatment of Cerebellar Ataxia.

Srinivasan SR, Huang H, Chang WC, Nasburg JA, Nguyen HM, Strassmaier T, Wulff H, Shakkottai VG. Srinivasan SR, et al. Among authors: wulff h. Mol Pharmacol. 2022 Jul;102(1):438-449. doi: 10.1124/molpharm.121.000478. Epub 2022 Apr 30. Mol Pharmacol. 2022. PMID: 35489717 Free PMC article.

6

Modulators of small- and intermediate-conductance calcium-activated potassium channels and their therapeutic indications.

Wulff H, Kolski-Andreaco A, Sankaranarayanan A, Sabatier JM, Shakkottai V. Wulff H, et al. Curr Med Chem. 2007;14(13):1437-57. doi: 10.2174/092986707780831186. Curr Med Chem. 2007. PMID: 17584055 Review.

7

Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure.

Sankaranarayanan A, Raman G, Busch C, Schultz T, Zimin PI, Hoyer J, Köhler R, Wulff H. Sankaranarayanan A, et al. Among authors: wulff h. Mol Pharmacol. 2009 Feb;75(2):281-95. doi: 10.1124/mol.108.051425. Epub 2008 Oct 27. Mol Pharmacol. 2009. PMID: 18955585 Free PMC article.

8

Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2.

Shakkottai VG, Regaya I, Wulff H, Fajloun Z, Tomita H, Fathallah M, Cahalan MD, Gargus JJ, Sabatier JM, Chandy KG. Shakkottai VG, et al. Among authors: wulff h. J Biol Chem. 2001 Nov 16;276(46):43145-51. doi: 10.1074/jbc.M106981200. Epub 2001 Aug 29. J Biol Chem. 2001. PMID: 11527975 Free article.

9

Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases.

Schmitz A, Sankaranarayanan A, Azam P, Schmidt-Lassen K, Homerick D, Hänsel W, Wulff H. Schmitz A, et al. Among authors: wulff h. Mol Pharmacol. 2005 Nov;68(5):1254-70. doi: 10.1124/mol.105.015669. Epub 2005 Aug 11. Mol Pharmacol. 2005. PMID: 16099841

10

Targeting effector memory T cells with the small molecule Kv1.3 blocker PAP-1 suppresses allergic contact dermatitis.

Azam P, Sankaranarayanan A, Homerick D, Griffey S, Wulff H. Azam P, et al. Among authors: wulff h. J Invest Dermatol. 2007 Jun;127(6):1419-29. doi: 10.1038/sj.jid.5700717. Epub 2007 Feb 1. J Invest Dermatol. 2007. PMID: 17273162 Free PMC article.

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