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Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation.
Chen X, Sunkel B, Wang M, Kang S, Wang T, Gnanaprakasam JNR, Liu L, Cassel TA, Scott DA, Muñoz-Cabello AM, Lopez-Barneo J, Yang J, Lane AN, Xin G, Stanton BZ, Fan TW, Wang R. Chen X, et al. Among authors: xin g. Sci Immunol. 2022 Apr 29;7(70):eabm8161. doi: 10.1126/sciimmunol.abm8161. Epub 2022 Apr 29. Sci Immunol. 2022. PMID: 35486677 Free PMC article.
Asparagine restriction enhances CD8+ T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response.
Gnanaprakasam JNR, Kushwaha B, Liu L, Chen X, Kang S, Wang T, Cassel TA, Adams CM, Higashi RM, Scott DA, Xin G, Li Z, Yang J, Lane AN, Fan TW, Zhang J, Wang R. Gnanaprakasam JNR, et al. Among authors: xin g. Nat Metab. 2023 Aug;5(8):1423-1439. doi: 10.1038/s42255-023-00856-1. Epub 2023 Aug 7. Nat Metab. 2023. PMID: 37550596 Free PMC article.
CD200R signaling contributes to unfavorable tumor microenvironment through regulating production of chemokines by tumor-associated myeloid cells.
Lin CH, Talebian F, Li Y, Zhu J, Liu JQ, Zhao B, Basu S, Pan X, Chen X, Yan P, Carson WE, Xin G, Wen H, Wang R, Li Z, Ma Q, Bai XF. Lin CH, et al. Among authors: xin g. iScience. 2023 May 19;26(6):106904. doi: 10.1016/j.isci.2023.106904. eCollection 2023 Jun 16. iScience. 2023. PMID: 37275530 Free PMC article.
SUSD2 suppresses CD8+ T cell antitumor immunity by targeting IL-2 receptor signaling.
Zhao B, Gong W, Ma A, Chen J, Velegraki M, Dong H, Liu Z, Wang L, Okimoto T, Jones DM, Lei YL, Long M, Oestreich KJ, Ma Q, Xin G, Carbone DP, He K, Li Z, Wen H. Zhao B, et al. Among authors: xin g. Nat Immunol. 2022 Nov;23(11):1588-1599. doi: 10.1038/s41590-022-01326-8. Epub 2022 Oct 20. Nat Immunol. 2022. PMID: 36266363 Free PMC article.
Aiolos represses CD4+ T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity.
Read KA, Jones DM, Pokhrel S, Hales EDS, Varkey A, Tuazon JA, Eisele CD, Abdouni O, Saadey A, Leonard MR, Warren RT, Powell MD, Boss JM, Hemann EA, Yount JS, Xin G, Ghoneim HE, Lio CJ, Freud AG, Collins PL, Oestreich KJ. Read KA, et al. Among authors: xin g. Nat Commun. 2023 Mar 24;14(1):1652. doi: 10.1038/s41467-023-37420-0. Nat Commun. 2023. PMID: 36964178 Free PMC article.
Targeting metabolic sensing switch GPR84 on macrophages for cancer immunotherapy.
Li J, Ma A, Zhang R, Chen Y, Bolyard C, Zhao B, Wang C, Pich T, Li W, Sun N, Ma Q, Wen H, Clinton SK, Carson WE 3rd, Li Z, Xin G. Li J, et al. Among authors: xin g. Cancer Immunol Immunother. 2024 Feb 13;73(3):52. doi: 10.1007/s00262-023-03603-3. Cancer Immunol Immunother. 2024. PMID: 38349405 Free PMC article.
577 results