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GTPase activity plays a key role in the pathobiology of LRRK2.
Xiong Y, Coombes CE, Kilaru A, Li X, Gitler AD, Bowers WJ, Dawson VL, Dawson TM, Moore DJ. Xiong Y, et al. PLoS Genet. 2010 Apr 8;6(4):e1000902. doi: 10.1371/journal.pgen.1000902. PLoS Genet. 2010. PMID: 20386743 Free PMC article.
Models of LRRK2-Associated Parkinson's Disease.
Xiong Y, Dawson TM, Dawson VL. Xiong Y, et al. Adv Neurobiol. 2017;14:163-191. doi: 10.1007/978-3-319-49969-7_9. Adv Neurobiol. 2017. PMID: 28353284 Free PMC article. Review.
Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice.
Xiong Y, Neifert S, Karuppagounder SS, Liu Q, Stankowski JN, Lee BD, Ko HS, Lee Y, Grima JC, Mao X, Jiang H, Kang SU, Swing DA, Iacovitti L, Tessarollo L, Dawson TM, Dawson VL. Xiong Y, et al. Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1635-1640. doi: 10.1073/pnas.1712648115. Epub 2018 Jan 31. Proc Natl Acad Sci U S A. 2018. PMID: 29386392 Free PMC article.
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