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Carfilzomib, rituximab, and dexamethasone (CaRD) treatment offers a neuropathy-sparing approach for treating Waldenström's macroglobulinemia.
Treon SP, Tripsas CK, Meid K, Kanan S, Sheehy P, Chuma S, Xu L, Cao Y, Yang G, Liu X, Patterson CJ, Warren D, Hunter ZR, Turnbull B, Ghobrial IM, Castillo JJ. Treon SP, et al. Among authors: xu l. Blood. 2014 Jul 24;124(4):503-10. doi: 10.1182/blood-2014-03-566273. Epub 2014 May 23. Blood. 2014. PMID: 24859363 Free article. Clinical Trial.
Protein kinase C inhibitor enzastaurin induces in vitro and in vivo antitumor activity in Waldenstrom macroglobulinemia.
Moreau AS, Jia X, Ngo HT, Leleu X, O'Sullivan G, Alsayed Y, Leontovich A, Podar K, Kutok J, Daley J, Lazo-Kallanian S, Hatjiharissi E, Raab MS, Xu L, Treon SP, Hideshima T, Anderson KC, Ghobrial IM. Moreau AS, et al. Among authors: xu l. Blood. 2007 Jun 1;109(11):4964-72. doi: 10.1182/blood-2006-10-054577. Epub 2007 Feb 6. Blood. 2007. PMID: 17284528 Free article.
Increased natural killer cell expression of CD16, augmented binding and ADCC activity to rituximab among individuals expressing the Fc{gamma}RIIIa-158 V/V and V/F polymorphism.
Hatjiharissi E, Xu L, Santos DD, Hunter ZR, Ciccarelli BT, Verselis S, Modica M, Cao Y, Manning RJ, Leleu X, Dimmock EA, Kortsaris A, Mitsiades C, Anderson KC, Fox EA, Treon SP. Hatjiharissi E, et al. Among authors: xu l. Blood. 2007 Oct 1;110(7):2561-4. doi: 10.1182/blood-2007-01-070656. Epub 2007 May 2. Blood. 2007. PMID: 17475906 Free PMC article.
Novel agents in the treatment of Waldenström's macroglobulinemia.
Treon SP, Hatjiharissi E, Leleu X, Moreau AS, Roccaro A, Hunter ZR, Soumerai JD, Ciccarelli B, Xu L, Sacco A, Ngo HT, Jia X, Yang C, Adamia S, Branagan AR, Ho AW, Santos DD, Tournilhac O, Manning RJ, Leduc R, O'Connor K, Nelson M, Patterson CJ, Ghobrial I. Treon SP, et al. Among authors: xu l. Clin Lymphoma Myeloma. 2007 Aug;7 Suppl 5:S199-206. doi: 10.3816/clm.2007.s.023. Clin Lymphoma Myeloma. 2007. PMID: 17877845 Review.
CD27-CD70 interactions in the pathogenesis of Waldenstrom macroglobulinemia.
Ho AW, Hatjiharissi E, Ciccarelli BT, Branagan AR, Hunter ZR, Leleu X, Tournilhac O, Xu L, O'Connor K, Manning RJ, Santos DD, Chemaly M, Patterson CJ, Soumerai JD, Munshi NC, McEarchern JA, Law CL, Grewal IS, Treon SP. Ho AW, et al. Among authors: xu l. Blood. 2008 Dec 1;112(12):4683-9. doi: 10.1182/blood-2007-04-084525. Epub 2008 Jan 23. Blood. 2008. PMID: 18216294 Free PMC article.
Endoplasmic reticulum stress is a target for therapy in Waldenstrom macroglobulinemia.
Leleu X, Xu L, Jia X, Sacco A, Farag M, Hunter ZR, Moreau AS, Ngo HT, Hatjiharissi E, Ho AW, Santos DD, Adamia S, O'Connor K, Ciccarelli B, Soumerai J, Manning RJ, Patterson CJ, Roccaro AM, Ghobrial IM, Treon SP. Leleu X, et al. Among authors: xu l. Blood. 2009 Jan 15;113(3):626-34. doi: 10.1182/blood-2007-10-116848. Epub 2008 Nov 3. Blood. 2009. PMID: 18981296 Free article.
Soluble CD27 is a faithful marker of disease burden and is unaffected by the rituximab-induced IgM flare, as well as by plasmapheresis, in patients with Waldenström's macroglobulinemia.
Ciccarelli BT, Yang G, Hatjiharissi E, Ioakimidis L, Patterson CJ, Manning RJ, Xu L, Liu X, Tseng H, Gong P, Sun J, Zhou Y, Treon SP. Ciccarelli BT, et al. Among authors: xu l. Clin Lymphoma Myeloma. 2009 Mar;9(1):56-8. doi: 10.3816/CLM.2009.n.014. Clin Lymphoma Myeloma. 2009. PMID: 19362974
IgA and IgG hypogammaglobulinemia in Waldenström's macroglobulinemia.
Hunter ZR, Manning RJ, Hanzis C, Ciccarelli BT, Ioakimidis L, Patterson CJ, Lewicki MC, Tseng H, Gong P, Liu X, Zhou Y, Yang G, Sun J, Xu L, Sheehy P, Morra M, Treon SP. Hunter ZR, et al. Among authors: xu l. Haematologica. 2010 Mar;95(3):470-5. doi: 10.3324/haematol.2009.010348. Epub 2009 Nov 10. Haematologica. 2010. PMID: 19903677 Free PMC article.
Histone deacetylase inhibitors demonstrate significant preclinical activity as single agents, and in combination with bortezomib in Waldenström's macroglobulinemia.
Sun JY, Xu L, Tseng H, Ciccarelli B, Fulciniti M, Hunter ZR, Maghsoudi K, Hatjiharissi E, Zhou Y, Yang G, Zhu B, Liu X, Gong P, Ioakimidis L, Sheehy P, Patterson CJ, Munshi NC, O'Connor OA, Treon SP. Sun JY, et al. Among authors: xu l. Clin Lymphoma Myeloma Leuk. 2011 Feb;11(1):152-6. doi: 10.3816/CLML.2011.n.036. Clin Lymphoma Myeloma Leuk. 2011. PMID: 21454220
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