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Simvastatin-Induced Apoptosis in Osteosarcoma Cells: A Key Role of RhoA-AMPK/p38 MAPK Signaling in Antitumor Activity.
Mol Cancer Ther. 2017 Jan;16(1):182-192. doi: 10.1158/1535-7163.MCT-16-0499. Epub 2016 Oct 31.
Mol Cancer Ther. 2017.
PMID: 27799356
IGF2 preserves osteosarcoma cell survival by creating an autophagic state of dormancy that protects cells against chemotherapeutic stress.
Shimizu T, Sugihara E, Yamaguchi-Iwai S, Tamaki S, Koyama Y, Kamel W, Ueki A, Ishikawa T, Chiyoda T, Osuka S, Onishi N, Ikeda H, Kamei J, Matsuo K, Fukuchi Y, Nagai T, Toguchida J, Toyama Y, Muto A, Saya H.
Shimizu T, et al. Among authors: yamaguchi iwai s.
Cancer Res. 2014 Nov 15;74(22):6531-41. doi: 10.1158/0008-5472.CAN-14-0914. Epub 2014 Oct 1.
Cancer Res. 2014.
PMID: 25273088
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Calcitriol exerts an anti-tumor effect in osteosarcoma by inducing the endoplasmic reticulum stress response.
Shimizu T, Kamel WA, Yamaguchi-Iwai S, Fukuchi Y, Muto A, Saya H.
Shimizu T, et al. Among authors: yamaguchi iwai s.
Cancer Sci. 2017 Sep;108(9):1793-1802. doi: 10.1111/cas.13304. Epub 2017 Jul 16.
Cancer Sci. 2017.
PMID: 28643892
Free PMC article.
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ROCK Inhibition Induces Terminal Adipocyte Differentiation and Suppresses Tumorigenesis in Chemoresistant Osteosarcoma Cells.
Takahashi N, Nobusue H, Shimizu T, Sugihara E, Yamaguchi-Iwai S, Onishi N, Kunitomi H, Kuroda T, Saya H.
Takahashi N, et al. Among authors: yamaguchi iwai s.
Cancer Res. 2019 Jun 15;79(12):3088-3099. doi: 10.1158/0008-5472.CAN-18-2693. Epub 2019 Apr 16.
Cancer Res. 2019.
PMID: 30992323
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MEK inhibition preferentially suppresses anchorage-independent growth in osteosarcoma cells and decreases tumors in vivo.
Shimizu T, Kimura K, Sugihara E, Yamaguchi-Iwai S, Nobusue H, Sampetrean O, Otsuki Y, Fukuchi Y, Saitoh K, Kato K, Soga T, Muto A, Saya H.
Shimizu T, et al. Among authors: yamaguchi iwai s.
J Orthop Res. 2021 Dec;39(12):2732-2743. doi: 10.1002/jor.25023. Epub 2021 Mar 26.
J Orthop Res. 2021.
PMID: 33751653
Free article.
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Depletion of R270C Mutant p53 in Osteosarcoma Attenuates Cell Growth but Does Not Prevent Invasion and Metastasis In Vivo.
Shimizu T, Sugihara E, Takeshima H, Nobusue H, Yamaguchi R, Yamaguchi-Iwai S, Fukuchi Y, Ushijima T, Muto A, Saya H.
Shimizu T, et al. Among authors: yamaguchi iwai s.
Cells. 2022 Nov 15;11(22):3614. doi: 10.3390/cells11223614.
Cells. 2022.
PMID: 36429043
Free PMC article.
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