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Transforming growth factor beta 1 induces proliferation in colon carcinoma cells by Ras-dependent, smad-independent down-regulation of p21cip1.
Yan Z, Kim GY, Deng X, Friedman E. Yan Z, et al. J Biol Chem. 2002 Mar 22;277(12):9870-9. doi: 10.1074/jbc.M107646200. Epub 2002 Jan 9. J Biol Chem. 2002. PMID: 11784716 Free article.
We recently demonstrated that colon carcinoma cells transfected with oncogenic cellular K-rasV12, but not oncogenic cellular H-rasV12, switched from TGFbeta1-insensitive to TGFbeta1-growth-stimulated and also became more invasive (Yan, Z., Deng, X., and Friedman, E. …
We recently demonstrated that colon carcinoma cells transfected with oncogenic cellular K-rasV12, but not oncogenic cellular H-rasV12, switc …
The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation.
Kim GY, Mercer SE, Ewton DZ, Yan Z, Jin K, Friedman E. Kim GY, et al. Among authors: yan z. J Biol Chem. 2002 Aug 16;277(33):29792-802. doi: 10.1074/jbc.M201299200. Epub 2002 Jun 10. J Biol Chem. 2002. PMID: 12058028 Free article.
TGF-beta 1 was previously shown to increase p21 protein levels, which in turn mediated G(1) arrest through inactivation of the CDK2-cyclin E complex in HD3 cells (Yan, Z., Kim, G.-Y., Deng, X., and Friedman, E. (2002) J. Biol. ...
TGF-beta 1 was previously shown to increase p21 protein levels, which in turn mediated G(1) arrest through inactivation of the CDK2-cyclin E …
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