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CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction.
Yang D, Cho H, Tayyebi Z, Shukla A, Luo R, Dixon G, Ursu V, Stransky S, Tremmel DM, Sackett SD, Koche R, Kaplan SJ, Li QV, Park J, Zhu Z, Rosen BP, Pulecio J, Shi ZD, Bram Y, Schwartz RE, Odorico JS, Sidoli S, Wright CV, Leslie CS, Huangfu D. Yang D, et al. Nat Cell Biol. 2022 Jul;24(7):1064-1076. doi: 10.1038/s41556-022-00946-4. Epub 2022 Jul 4. Nat Cell Biol. 2022. PMID: 35787684 Free PMC article.
DICER1 Is Essential for Self-Renewal of Human Embryonic Stem Cells.
Teijeiro V, Yang D, Majumdar S, González F, Rickert RW, Xu C, Koche R, Verma N, Lai EC, Huangfu D. Teijeiro V, et al. Among authors: yang d. Stem Cell Reports. 2018 Sep 11;11(3):616-625. doi: 10.1016/j.stemcr.2018.07.013. Epub 2018 Aug 23. Stem Cell Reports. 2018. PMID: 30146489 Free PMC article.
Genome-scale screens identify JNK-JUN signaling as a barrier for pluripotency exit and endoderm differentiation.
Li QV, Dixon G, Verma N, Rosen BP, Gordillo M, Luo R, Xu C, Wang Q, Soh CL, Yang D, Crespo M, Shukla A, Xiang Q, Dündar F, Zumbo P, Witkin M, Koche R, Betel D, Chen S, Massagué J, Garippa R, Evans T, Beer MA, Huangfu D. Li QV, et al. Among authors: yang d. Nat Genet. 2019 Jun;51(6):999-1010. doi: 10.1038/s41588-019-0408-9. Epub 2019 May 20. Nat Genet. 2019. PMID: 31110351 Free PMC article.
QSER1 protects DNA methylation valleys from de novo methylation.
Dixon G, Pan H, Yang D, Rosen BP, Jashari T, Verma N, Pulecio J, Caspi I, Lee K, Stransky S, Glezer A, Liu C, Rivas M, Kumar R, Lan Y, Torregroza I, He C, Sidoli S, Evans T, Elemento O, Huangfu D. Dixon G, et al. Among authors: yang d. Science. 2021 Apr 9;372(6538):eabd0875. doi: 10.1126/science.abd0875. Science. 2021. PMID: 33833093 Free PMC article.
Epithelial cell plasticity drives endoderm formation during gastrulation.
Scheibner K, Schirge S, Burtscher I, Büttner M, Sterr M, Yang D, Böttcher A, Ansarullah, Irmler M, Beckers J, Cernilogar FM, Schotta G, Theis FJ, Lickert H. Scheibner K, et al. Among authors: yang d. Nat Cell Biol. 2021 Jul;23(7):692-703. doi: 10.1038/s41556-021-00694-x. Epub 2021 Jun 24. Nat Cell Biol. 2021. PMID: 34168324 Free PMC article.
Publisher Correction: Epithelial cell plasticity drives endoderm formation during gastrulation.
Scheibner K, Schirge S, Burtscher I, Büttner M, Sterr M, Yang D, Böttcher A, Ansarullah, Irmler M, Beckers J, Cernilogar FM, Schotta G, Theis FJ, Lickert H. Scheibner K, et al. Among authors: yang d. Nat Cell Biol. 2021 Aug;23(8):925. doi: 10.1038/s41556-021-00735-5. Nat Cell Biol. 2021. PMID: 34294885 Free PMC article. No abstract available.
Dynamic network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer gene regulatory activity during cell state transitions.
Luo R, Yan J, Oh JW, Xi W, Shigaki D, Wong W, Cho HS, Murphy D, Cutler R, Rosen BP, Pulecio J, Yang D, Glenn RA, Chen T, Li QV, Vierbuchen T, Sidoli S, Apostolou E, Huangfu D, Beer MA. Luo R, et al. Among authors: yang d. Nat Genet. 2023 Aug;55(8):1336-1346. doi: 10.1038/s41588-023-01450-7. Epub 2023 Jul 24. Nat Genet. 2023. PMID: 37488417 Free PMC article.
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