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Potent and broad HIV-neutralizing antibodies in memory B cells and plasma.
Williams LD, Ofek G, Schätzle S, McDaniel JR, Lu X, Nicely NI, Wu L, Lougheed CS, Bradley T, Louder MK, McKee K, Bailer RT, O'Dell S, Georgiev IS, Seaman MS, Parks RJ, Marshall DJ, Anasti K, Yang G, Nie X, Tumba NL, Wiehe K, Wagh K, Korber B, Kepler TB, Munir Alam S, Morris L, Kamanga G, Cohen MS, Bonsignori M, Xia SM, Montefiori DC, Kelsoe G, Gao F, Mascola JR, Moody MA, Saunders KO, Liao HX, Tomaras GD, Georgiou G, Haynes BF. Williams LD, et al. Among authors: yang g. Sci Immunol. 2017 Jan 27;2(7):eaal2200. doi: 10.1126/sciimmunol.aal2200. Sci Immunol. 2017. PMID: 28783671 Free PMC article.
Isolation of HIV-1-neutralizing mucosal monoclonal antibodies from human colostrum.
Friedman J, Alam SM, Shen X, Xia SM, Stewart S, Anasti K, Pollara J, Fouda GG, Yang G, Kelsoe G, Ferrari G, Tomaras GD, Haynes BF, Liao HX, Moody MA, Permar SR. Friedman J, et al. Among authors: yang g. PLoS One. 2012;7(5):e37648. doi: 10.1371/journal.pone.0037648. Epub 2012 May 18. PLoS One. 2012. PMID: 22624058 Free PMC article.
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus.
Liao HX, Lynch R, Zhou T, Gao F, Alam SM, Boyd SD, Fire AZ, Roskin KM, Schramm CA, Zhang Z, Zhu J, Shapiro L; NISC Comparative Sequencing Program; Mullikin JC, Gnanakaran S, Hraber P, Wiehe K, Kelsoe G, Yang G, Xia SM, Montefiori DC, Parks R, Lloyd KE, Scearce RM, Soderberg KA, Cohen M, Kamanga G, Louder MK, Tran LM, Chen Y, Cai F, Chen S, Moquin S, Du X, Joyce MG, Srivatsan S, Zhang B, Zheng A, Shaw GM, Hahn BH, Kepler TB, Korber BT, Kwong PD, Mascola JR, Haynes BF. Liao HX, et al. Among authors: yang g. Nature. 2013 Apr 25;496(7446):469-76. doi: 10.1038/nature12053. Epub 2013 Apr 3. Nature. 2013. PMID: 23552890 Free PMC article.
Polyreactivity and autoreactivity among HIV-1 antibodies.
Liu M, Yang G, Wiehe K, Nicely NI, Vandergrift NA, Rountree W, Bonsignori M, Alam SM, Gao J, Haynes BF, Kelsoe G. Liu M, et al. Among authors: yang g. J Virol. 2015 Jan;89(1):784-98. doi: 10.1128/JVI.02378-14. Epub 2014 Oct 29. J Virol. 2015. PMID: 25355869 Free PMC article.
HIV-1 Envelope Mimicry of Host Enzyme Kynureninase Does Not Disrupt Tryptophan Metabolism.
Bradley T, Yang G, Ilkayeva O, Holl TM, Zhang R, Zhang J, Santra S, Fox CB, Reed SG, Parks R, Bowman CM, Bouton-Verville H, Sutherland LL, Scearce RM, Vandergrift N, Kepler TB, Moody MA, Liao HX, Alam SM, McLendon R, Everitt JI, Newgard CB, Verkoczy L, Kelsoe G, Haynes BF. Bradley T, et al. Among authors: yang g. J Immunol. 2016 Dec 15;197(12):4663-4673. doi: 10.4049/jimmunol.1601484. Epub 2016 Nov 14. J Immunol. 2016. PMID: 27849170 Free PMC article.
An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1.
Bonsignori M, Wiehe K, Grimm SK, Lynch R, Yang G, Kozink DM, Perrin F, Cooper AJ, Hwang KK, Chen X, Liu M, McKee K, Parks RJ, Eudailey J, Wang M, Clowse M, Criscione-Schreiber LG, Moody MA, Ackerman ME, Boyd SD, Gao F, Kelsoe G, Verkoczy L, Tomaras GD, Liao HX, Kepler TB, Montefiori DC, Mascola JR, Haynes BF. Bonsignori M, et al. Among authors: yang g. J Clin Invest. 2014 Apr;124(4):1835-43. doi: 10.1172/JCI73441. Epub 2014 Mar 10. J Clin Invest. 2014. PMID: 24614107 Free PMC article.
Self-tolerance curtails the B cell repertoire to microbial epitopes.
Watanabe A, Su KY, Kuraoka M, Yang G, Reynolds AE, Schmidt AG, Harrison SC, Haynes BF, St Clair EW, Kelsoe G. Watanabe A, et al. Among authors: yang g. JCI Insight. 2019 May 16;4(10):e122551. doi: 10.1172/jci.insight.122551. eCollection 2019 May 16. JCI Insight. 2019. PMID: 31092727 Free PMC article. Clinical Trial.
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