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Design, synthesis, and progress toward optimization of potent small molecule antagonists of CC chemokine receptor 8 (CCR8).
Ghosh S, Elder A, Guo J, Mani U, Patane M, Carson K, Ye Q, Bennett R, Chi S, Jenkins T, Guan B, Kolbeck R, Smith S, Zhang C, LaRosa G, Jaffee B, Yang H, Eddy P, Lu C, Uttamsingh V, Horlick R, Harriman G, Flynn D. Ghosh S, et al. Among authors: yang h. J Med Chem. 2006 May 4;49(9):2669-72. doi: 10.1021/jm050965z. J Med Chem. 2006. PMID: 16640325
Novel benzimidazole derivatives as selective CB2 agonists.
Pagé D, Balaux E, Boisvert L, Liu Z, Milburn C, Tremblay M, Wei Z, Woo S, Luo X, Cheng YX, Yang H, Srivastava S, Zhou F, Brown W, Tomaszewski M, Walpole C, Hodzic L, St-Onge S, Godbout C, Salois D, Payza K. Pagé D, et al. Among authors: yang h. Bioorg Med Chem Lett. 2008 Jul 1;18(13):3695-700. doi: 10.1016/j.bmcl.2008.05.073. Epub 2008 May 22. Bioorg Med Chem Lett. 2008. PMID: 18522867
N-Methyl-3-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamides as a novel class of cannabinoid receptors agonists with low CNS penetration.
Wei Z, Yang H, Liu Z, Tremblay M, Johnstone S, Béha S, Yue SY, Srivastava S, Tomaszewski MJ, Brown W, Walpole C, St-Onge S, Lessard E, Archambault AJ, Groblewski T, Pagé D. Wei Z, et al. Among authors: yang h. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3884-9. doi: 10.1016/j.bmcl.2012.04.128. Epub 2012 May 4. Bioorg Med Chem Lett. 2012. PMID: 22607668
Aminotriazine 5-HT7 antagonists.
Mattson RJ, Denhart DJ, Catt JD, Dee MF, Deskus JA, Ditta JL, Epperson J, Dalton King H, Gao A, Poss MA, Purandare A, Tortolani D, Zhao Y, Yang H, Yeola S, Palmer J, Torrente J, Stark A, Johnson G. Mattson RJ, et al. Among authors: yang h. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4245-8. doi: 10.1016/j.bmcl.2004.06.008. Bioorg Med Chem Lett. 2004. PMID: 15261279
N,N-Diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide: a novel, exceptionally selective, potent delta opioid receptor agonist with oral bioavailability and its analogues.
Wei ZY, Brown W, Takasaki B, Plobeck N, Delorme D, Zhou F, Yang H, Jones P, Gawell L, Gagnon H, Schmidt R, Yue SY, Walpole C, Payza K, St-Onge S, Labarre M, Godbout C, Jakob A, Butterworth J, Kamassah A, Morin PE, Projean D, Ducharme J, Roberts E. Wei ZY, et al. Among authors: yang h. J Med Chem. 2000 Oct 19;43(21):3895-905. doi: 10.1021/jm000229p. J Med Chem. 2000. PMID: 11052794
New diarylmethylpiperazines as potent and selective nonpeptidic delta opioid receptor agonists with increased In vitro metabolic stability.
Plobeck N, Delorme D, Wei ZY, Yang H, Zhou F, Schwarz P, Gawell L, Gagnon H, Pelcman B, Schmidt R, Yue SY, Walpole C, Brown W, Zhou E, Labarre M, Payza K, St-Onge S, Kamassah A, Morin PE, Projean D, Ducharme J, Roberts E. Plobeck N, et al. Among authors: yang h. J Med Chem. 2000 Oct 19;43(21):3878-94. doi: 10.1021/jm000228x. J Med Chem. 2000. PMID: 11052793
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