Asn415 in the beta11-beta12 linker decreases proton-dependent desensitization of ASIC1.
Li T, Yang Y, Canessa CM.
Li T, et al. Among authors: yang y.
J Biol Chem. 2010 Oct 8;285(41):31285-91. doi: 10.1074/jbc.M110.160382. Epub 2010 Jul 30.
J Biol Chem. 2010.
PMID: 20675379
Free PMC article.
This property is important physiologically and also can be exploited to develop strategies to increase or decrease the channel response to protons. In a previous study (Li, T., Yang, Y., and Canessa, C. M. (2010) J. Biol. Chem. 285, 22706-22712), we found that Leu-8 …
This property is important physiologically and also can be exploited to develop strategies to increase or decrease the channel response to p …