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Development of prodrug 4-chloro-3-(5-methyl-3-{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}-1,2,4-benzotriazin-7-yl)phenyl benzoate (TG100801): a topically administered therapeutic candidate in clinical trials for the treatment of age-related macular degeneration.
Palanki MS, Akiyama H, Campochiaro P, Cao J, Chow CP, Dellamary L, Doukas J, Fine R, Gritzen C, Hood JD, Hu S, Kachi S, Kang X, Klebansky B, Kousba A, Lohse D, Mak CC, Martin M, McPherson A, Pathak VP, Renick J, Soll R, Umeda N, Yee S, Yokoi K, Zeng B, Zhu H, Noronha G. Palanki MS, et al. Among authors: yokoi k. J Med Chem. 2008 Mar 27;51(6):1546-59. doi: 10.1021/jm7011276. Epub 2008 Feb 27. J Med Chem. 2008. PMID: 18311895
Oxidative stress promotes ocular neovascularization.
Dong A, Xie B, Shen J, Yoshida T, Yokoi K, Hackett SF, Campochiaro PA. Dong A, et al. Among authors: yokoi k. J Cell Physiol. 2009 Jun;219(3):544-52. doi: 10.1002/jcp.21698. J Cell Physiol. 2009. PMID: 19142872 Free PMC article.
Mecamylamine suppresses Basal and nicotine-stimulated choroidal neovascularization.
Kiuchi K, Matsuoka M, Wu JC, Lima e Silva R, Kengatharan M, Verghese M, Ueno S, Yokoi K, Khu NH, Cooke JP, Campochiaro PA. Kiuchi K, et al. Among authors: yokoi k. Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1705-11. doi: 10.1167/iovs.07-0089. Invest Ophthalmol Vis Sci. 2008. PMID: 18385094 Free PMC article.
Ocular gene transfer with self-complementary AAV vectors.
Yokoi K, Kachi S, Zhang HS, Gregory PD, Spratt SK, Samulski RJ, Campochiaro PA. Yokoi K, et al. Invest Ophthalmol Vis Sci. 2007 Jul;48(7):3324-8. doi: 10.1167/iovs.06-1306. Invest Ophthalmol Vis Sci. 2007. PMID: 17591905
989 results