Young LN - Search Results

1

Structural pathway for allosteric activation of the autophagic PI 3-kinase complex I.

Young LN, Goerdeler F, Hurley JH. Young LN, et al. Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21508-21513. doi: 10.1073/pnas.1911612116. Epub 2019 Oct 7. Proc Natl Acad Sci U S A. 2019. PMID: 31591221 Free PMC article.

2

Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex.

Baskaran S, Carlson LA, Stjepanovic G, Young LN, Kim DJ, Grob P, Stanley RE, Nogales E, Hurley JH. Baskaran S, et al. Among authors: young ln. Elife. 2014 Dec 9;3:e05115. doi: 10.7554/eLife.05115. Elife. 2014. PMID: 25490155 Free PMC article.

3

Dynamics and architecture of the NRBF2-containing phosphatidylinositol 3-kinase complex I of autophagy.

Young LN, Cho K, Lawrence R, Zoncu R, Hurley JH. Young LN, et al. Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8224-9. doi: 10.1073/pnas.1603650113. Epub 2016 Jul 6. Proc Natl Acad Sci U S A. 2016. PMID: 27385829 Free PMC article.

4

Mechanisms of Autophagy Initiation.

Hurley JH, Young LN. Hurley JH, et al. Among authors: young ln. Annu Rev Biochem. 2017 Jun 20;86:225-244. doi: 10.1146/annurev-biochem-061516-044820. Epub 2017 Mar 15. Annu Rev Biochem. 2017. PMID: 28301741 Free PMC article. Review.

5

Bidirectional Control of Autophagy by BECN1 BARA Domain Dynamics.

Chang C, Young LN, Morris KL, von Bülow S, Schöneberg J, Yamamoto-Imoto H, Oe Y, Yamamoto K, Nakamura S, Stjepanovic G, Hummer G, Yoshimori T, Hurley JH. Chang C, et al. Among authors: young ln. Mol Cell. 2019 Jan 17;73(2):339-353.e6. doi: 10.1016/j.molcel.2018.10.035. Epub 2018 Dec 20. Mol Cell. 2019. PMID: 30581147 Free PMC article.

6

The BARA necessities of PtdIns 3-kinase activation in autophagy.

Chang C, Young LN, Hurley JH. Chang C, et al. Among authors: young ln. Autophagy. 2019 Jun;15(6):1122-1123. doi: 10.1080/15548627.2019.1596501. Epub 2019 Mar 30. Autophagy. 2019. PMID: 30894086 Free PMC article.

7

Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex.

Lawrence RE, Fromm SA, Fu Y, Yokom AL, Kim DJ, Thelen AM, Young LN, Lim CY, Samelson AJ, Hurley JH, Zoncu R. Lawrence RE, et al. Among authors: young ln. Science. 2019 Nov 22;366(6468):971-977. doi: 10.1126/science.aax0364. Epub 2019 Oct 31. Science. 2019. PMID: 31672913 Free PMC article.

8

ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer.

Shi X, Yokom AL, Wang C, Young LN, Youle RJ, Hurley JH. Shi X, et al. Among authors: young ln. J Cell Biol. 2020 Jul 6;219(7):e201911047. doi: 10.1083/jcb.201911047. J Cell Biol. 2020. PMID: 32516362 Free PMC article.

9

Increasing intracellular trehalose is sufficient to confer desiccation tolerance to Saccharomyces cerevisiae.

Tapia H, Young L, Fox D, Bertozzi CR, Koshland D. Tapia H, et al. Proc Natl Acad Sci U S A. 2015 May 12;112(19):6122-7. doi: 10.1073/pnas.1506415112. Epub 2015 Apr 27. Proc Natl Acad Sci U S A. 2015. PMID: 25918381 Free PMC article.

10

Bringing Structure to Cell Biology with Cryo-Electron Tomography.

Young LN, Villa E. Young LN, et al. Annu Rev Biophys. 2023 May 9;52:573-595. doi: 10.1146/annurev-biophys-111622-091327. Annu Rev Biophys. 2023. PMID: 37159298 Free PMC article. Review.

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