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Ubiquitin-proteasome pathway mediates degradation of APH-1.
He G, Qing H, Cai F, Kwok C, Xu H, Yu G, Bernstein A, Song W. He G, et al. Among authors: yu g. J Neurochem. 2006 Dec;99(5):1403-12. doi: 10.1111/j.1471-4159.2006.04184.x. Epub 2006 Oct 24. J Neurochem. 2006. PMID: 17059559 Free article.
Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin.
Levesque G, Yu G, Nishimura M, Zhang DM, Levesque L, Yu H, Xu D, Liang Y, Rogaeva E, Ikeda M, Duthie M, Murgolo N, Wang L, VanderVere P, Bayne ML, Strader CD, Rommens JM, Fraser PE, St George-Hyslop P. Levesque G, et al. Among authors: yu g, yu h. J Neurochem. 1999 Mar;72(3):999-1008. doi: 10.1046/j.1471-4159.1999.0720999.x. J Neurochem. 1999. PMID: 10037471 Free article.
Presenilin 1 is actively degraded by the 26S proteasome.
Fraser PE, Levesque G, Yu G, Mills LR, Thirlwell J, Frantseva M, Gandy SE, Seeger M, Carlen PL, St George-Hyslop P. Fraser PE, et al. Among authors: yu g. Neurobiol Aging. 1998 Jan-Feb;19(1 Suppl):S19-21. doi: 10.1016/s0197-4580(98)00029-3. Neurobiol Aging. 1998. PMID: 9562462 Free article.
Neprilysin activity and expression are controlled by nicastrin.
Pardossi-Piquard R, Dunys J, Yu G, St George-Hyslop P, Alves da Costa C, Checler F. Pardossi-Piquard R, et al. Among authors: yu g. J Neurochem. 2006 May;97(4):1052-6. doi: 10.1111/j.1471-4159.2006.03822.x. Epub 2006 Apr 5. J Neurochem. 2006. PMID: 16606360 Free article.
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing.
Yu G, Nishimura M, Arawaka S, Levitan D, Zhang L, Tandon A, Song YQ, Rogaeva E, Chen F, Kawarai T, Supala A, Levesque L, Yu H, Yang DS, Holmes E, Milman P, Liang Y, Zhang DM, Xu DH, Sato C, Rogaev E, Smith M, Janus C, Zhang Y, Aebersold R, Farrer LS, Sorbi S, Bruni A, Fraser P, St George-Hyslop P. Yu G, et al. Among authors: yu h. Nature. 2000 Sep 7;407(6800):48-54. doi: 10.1038/35024009. Nature. 2000. PMID: 10993067
Mutation of the conserved N-terminal cysteine (Cys92) of human presenilin 1 causes increased A beta42 secretion in mammalian cells but impaired Notch/lin-12 signalling in C. elegans.
Zhang DM, Levitan D, Yu G, Nishimura M, Chen F, Tandon A, Kawarai T, Arawaka S, Supala A, Song YQ, Rogaeva E, Liang Y, Holmes E, Milman P, Sato C, Zhang L, St George-Hyslop P. Zhang DM, et al. Among authors: yu g. Neuroreport. 2000 Sep 28;11(14):3227-30. doi: 10.1097/00001756-200009280-00035. Neuroreport. 2000. PMID: 11043553
9,536 results