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Toll-like receptor 4 signaling pathway is correlated with pathophysiological characteristics of AML patients and its inhibition using TAK-242 suppresses AML cell proliferation.
Baakhlagh S, Kashani B, Zandi Z, Bashash D, Moradkhani M, Nasrollahzadeh A, Yaghmaei M, Mousavi SA, Ghaffari SH. Baakhlagh S, et al. Among authors: zandi z. Int Immunopharmacol. 2021 Jan;90:107202. doi: 10.1016/j.intimp.2020.107202. Epub 2020 Dec 2. Int Immunopharmacol. 2021. PMID: 33278749
TLR4 blockade using TAK-242 suppresses ovarian and breast cancer cells invasion through the inhibition of extracellular matrix degradation and epithelial-mesenchymal transition.
Zandi Z, Kashani B, Poursani EM, Bashash D, Kabuli M, Momeny M, Mousavi-Pak SH, Sheikhsaran F, Alimoghaddam K, Mousavi SA, Ghaffari SH. Zandi Z, et al. Eur J Pharmacol. 2019 Jun 15;853:256-263. doi: 10.1016/j.ejphar.2019.03.046. Epub 2019 Mar 28. Eur J Pharmacol. 2019. PMID: 30930249
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