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Practical and efficient strategy for evaluating oral absolute bioavailability with an intravenous microdose of a stable isotopically-labeled drug using a selected reaction monitoring mass spectrometry assay.
Jiang H, Zeng J, Li W, Bifano M, Gu H, Titsch C, Easter J, Burrell R, Kandoussi H, Aubry AF, Arnold ME. Jiang H, et al. Among authors: zeng j. Anal Chem. 2012 Nov 20;84(22):10031-7. doi: 10.1021/ac3024558. Epub 2012 Nov 6. Anal Chem. 2012. PMID: 23106420
Simultaneous determination of a selective adenosine 2A agonist, BMS-068645, and its acid metabolite in human plasma by liquid chromatography-tandem mass spectrometry--evaluation of the esterase inhibitor, diisopropyl fluorophosphate, in the stabilization of a labile ester-containing drug.
Zeng J, Onthank D, Crane P, Unger S, Zheng N, Pasas-Farmer S, Arnold M. Zeng J, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jun 1;852(1-2):77-84. doi: 10.1016/j.jchromb.2006.12.054. Epub 2007 Jan 13. J Chromatogr B Analyt Technol Biomed Life Sci. 2007. PMID: 17280881
Liquid chromatography and tandem mass spectrometry for the quantitative determination of ixabepilone (BMS-247550, Ixempra) in human plasma: method validation, overcoming curve splitting issues and eliminating chromatographic interferences from degradants.
Xu XS, Zeng J, Mylott W, Arnold M, Waltrip J, Iacono L, Mariannino T, Stouffer B. Xu XS, et al. Among authors: zeng j. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Feb 15;878(5-6):525-37. doi: 10.1016/j.jchromb.2009.12.014. Epub 2009 Dec 16. J Chromatogr B Analyt Technol Biomed Life Sci. 2010. PMID: 20083444
9,121 results